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D3281

Supelco

Diflunisal

analytical standard

Synonyme(s) :

2′,4′-Difluoro-4-hydroxy-[1,1′-biphenyl]-3-carboxylic acid, 5-(2,4-Difluorophenyl)salicylic acid

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About This Item

Formule empirique (notation de Hill):
C13H8F2O3
Numéro CAS:
22494-42-4
Poids moléculaire :
250.20
Numéro CE :
245-034-9
Numéro MDL:
MFCD00057834
Code UNSPSC :
41116107
ID de substance PubChem :
329798693
Nomenclature NACRES :
NA.24

Qualité

analytical standard

Niveau de qualité

100

Technique(s)

HPLC: suitable
gas chromatography (GC): suitable

Application(s)

forensics and toxicology
pharmaceutical (small molecule)

Format

neat

Chaîne SMILES 

FC1=CC(F)=CC=C1C2=CC(C(O)=O)=C(O)C=C2

InChI

1S/C13H8F2O3/c14-8-2-3-9(11(15)6-8)7-1-4-12(16)10(5-7)13(17)18/h1-6,16H,(H,17,18)

Clé InChI

HUPFGZXOMWLGNK-UHFFFAOYSA-N

Informations sur le gène

human ... ALB(213) , PTGS1(5742) , PTGS2(5743)

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Application

Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

Pictogrammes

Health hazardExclamation mark
GHS08,GHS07

Mention d'avertissement

Warning

Mentions de danger

H302,H315,H319,H335,H361

Classification des risques

Acute Tox. 4 Oral - Eye Irrit. 2 - Repr. 2 - Skin Irrit. 2 - STOT SE 3

Organes cibles

Respiratory system

Code de la classe de stockage

11 - Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 3

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Équipement de protection individuelle

Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges

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Certificats d'analyse (COA)

Lot/Batch Number
SLBG0421V
MKCQ1736
MKCM4294
MKCK9268
MKCH2787

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Retrouvez la documentation relative aux produits que vous avez récemment achetés dans la Bibliothèque de documents.

Consulter la Bibliothèque de documents

Ellen Y Cotrina et al.
Journal of medicinal chemistry, 56(22), 9110-9121 (2013-10-24)
The amyloidogenic protein transthyretin (TTR) is thought to aggregate into amyloid fibrils by tetramer dissociation which can be inhibited by a number of small molecule compounds. Our analysis of a series of crystallographic protein-inhibitor complexes has shown no clear correlation
Teresa Mairal et al.
PloS one, 4(1), e4124-e4124 (2009-01-07)
The thyroid hormone and retinol transporter protein known as transthyretin (TTR) is in the origin of one of the 20 or so known amyloid diseases. TTR self assembles as a homotetramer leaving a central hydrophobic channel with two symmetrical binding
John L Berk et al.
Amyloid : the international journal of experimental and clinical investigation : the official journal of the International Society of Amyloidosis, 19 Suppl 1, 37-38 (2012-05-04)
Familial amyloidotic polyneuropathy (FAP) is a protein folding disorder that induces neuropathy and cardiomyopathy, leading to death within 7-15 years after onset of clinical disease. In vitro, small ligands binding the thyroid hormone docking site stabilize tetrameric transthyretin, inhibiting amyloid
Maria Esther Zugasti et al.
Drug development and industrial pharmacy, 35(10), 1264-1270 (2009-06-27)
The influence of beta-cyclodextrin (beta-CD) polymers on drug release from hydroxypropyl methylcellulose (HPMC) matrices has not been reported in the literature. The influence of monomeric beta-CD and both soluble and insoluble beta-CD polymers on drug release from tablets containing either
J A Murillo Pulgarín et al.
Analytica chimica acta, 625(1), 47-54 (2008-08-30)
The simultaneous determination of 6-methoxy-2-naphthylacetic acid (6MNA) and diflunisal in serum samples using the combination of matrix isopotential synchronous fluorescence (MISF) and first derivative technique is proposed. 6MNA and diflunisal exhibit overlapped spectra and serum produces background fluorescence that precludes
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