164598

Aminopeptidase M, Porcine Kidney

• Synonyme(s) : Aminopeptidase M, Porcine Kidney, Alanyl aminopeptidase, Aminopeptidase M, Aminopeptidase N
• Numéro CAS: 9054-63-1
• Numéro de classification (Commission des enzymes): 3.4.11.2 (BRENDA, IUBMB)
• Numéro MDL: MFCD00131501
• Code UNSPSC : 12352202
• Nomenclature NACRES : NA.54

Propriétés

• Source biologique: Porcine kidney
• Niveau de qualité: 100
• Forme: suspension (crystalline)
• Fabricant/nom de marque: Calbiochem^®
• Conditions de stockage: OK to freeze
• Couleur: white
• Solubilité: physiological buffer: soluble; water: soluble
• Activité étrangère: Oxidases ≤3%
• Conditions d'expédition: ambient
• Température de stockage: 2-8°C

Description

Description générale

Aminopeptidase M (APM) is abundantly found in brush border membranes of the kidney, small intestine, placenta, and liver. It is a type II integral membrane protein, known as ectoenzyme.

Application

Aminopeptidase M, porcine kidney has been used:

• to test and identify the peaks containing d-residue in the allatotropin-related peptide (ATRP)
• to study its oxidative inactivation of enzyme activity, and to screen MIRA ingredients
• for the proteolysis of isolevuglandins (IsoLGs) proteins

Actions biochimiques/physiologiques

Aminopeptidase M (APM) is implicated in terminating the actions of certain neuropeptides, like the enkephalins and angiotensin III in the brain. It also metabolizes specific vasoactive peptides. It functions as a receptor for certain viruses, such as coronavirus 229E. APM is a nonspecific peptidase, which rapidly breaks down l-residue peptides.

Conditionnement

Please refer to vial label for lot-specific concentration.

Avertissement

Toxicity: Harmful (C)

Définition de l'unité

One unit is defined as the amount of enzyme that will hydrolyze 1 µmol of Leu-pNA per min at 37°C, pH 7.2.

Forme physique

Crystalline suspension in 3.2 M (NH₄)₂SO₄, 10 mM MgCl₂, 10 mM Tris-HCl, pH 7.5.

Autres remarques

Wachsmuth, E.E., et al. 1966. Biochemistry5, 169.

Informations légales

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Informations sur la sécurité

• Code de la classe de stockage: 12 - Non Combustible Liquids
• Classe de danger pour l'eau (WGK): WGK 2
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable