- Total synthesis of broussonetine F: the orthoamide Overman rearrangement of an allylic diol.
Total synthesis of broussonetine F: the orthoamide Overman rearrangement of an allylic diol.
Organic letters (2011-01-05)
Naoto Hama, Toshihiro Aoki, Shohei Miwa, Miki Yamazaki, Takaaki Sato, Noritaka Chida
PMID21194237
RESUMO
A first total synthesis of broussonetine F from diethyl L-tartrate was achieved. The cornerstone of our synthesis was an orthoamide Overman rearrangement, which provided an allylic amino alcohol with complete diastereoselectivity.