1467848

Nobiletin

United States Pharmacopeia (USP) Reference Standard

• Sinônimo(s): 2-(3,4-Dimethoxyphenyl)-5,6,7,8-tetramethoxy-4H-1-benzopyran-4-one, 3′,4′,5,6,7,8-Hexamethoxyflavone
• Fórmula empírica (Notação de Hill): C₂₁H₂₂O₈
• Número CAS: 478-01-3
• Peso molecular: 402.39
• Beilstein: 360887
• Número MDL: MFCD03273560
• Código UNSPSC: 41116107
• NACRES: NA.24

Propriedades

• grau: pharmaceutical primary standard
• Agency: USP
• embalagem: pkg of 100 mg
• fabricante/nome comercial: USP
• aplicação(ões): pharmaceutical
• Formato: neat
• temperatura de armazenamento: −20°C
• cadeia de caracteres SMILES: COc1ccc(cc1OC)C2=CC(=O)c3c(OC)c(OC)c(OC)c(OC)c3O2
• InChI: 1S/C21H22O8/c1-23-13-8-7-11(9-15(13)24-2)14-10-12(22)16-17(25-3)19(26-4)21(28-6)20(27-5)18(16)29-14/h7-10H,1-6H3
• chave InChI: MRIAQLRQZPPODS-UHFFFAOYSA-N

Descrição

Descrição geral

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

Aplicação

Nobiletin USP reference standard, intended for use in specified quality tests and assays as specified in the USP compendia. Also, for use with USP monographs such as:

• Bitter Orange Young Fruit
• Bitter Orange Young Fruit Powder
• Tangerine Peel
• Tangerine Peel Dry Extract
• Tangerine Peel Powder

Ações bioquímicas/fisiológicas

Nobiletin suppresses the expression of matrix metalloproteinases 1, 3 and 9, which participate in the break down of the extracellular matrix during tumor metastasis. Nobiletin is also involved in the increased expression of tissue inhibitor of matrix metalloproteinase 1 further preventing extracellular matrix degradation during tumor invasion. This bioflavonoid is believed to achieve both of these functions by disrupting the signal transduction pathway of Ras-Raf-MEK.

Nota de análise

These products are for test and assay use only. They are not meant for administration to humans or animals and cannot be used to diagnose, treat, or cure diseases of any kind.  

Outras notas

Sales restrictions may apply.

Informações de segurança

• Código de classe de armazenamento: 11 - Combustible Solids
• Classe de risco de água (WGK): WGK 3
• Ponto de fulgor (°F): Not applicable
• Ponto de fulgor (°C): Not applicable