1285750

Flurbiprofen

United States Pharmacopeia (USP) Reference Standard

• Sinônimo(s): (±)-2-Fluoro-α-methyl-4-biphenylacetic acid, L-790,330
• Fórmula linear: C₆H₅C₆H₃(F)CH(CH₃)CO₂H
• Número CAS: 5104-49-4
• Peso molecular: 244.26
• Número MDL: MFCD00079303
• Código UNSPSC: 41116107
• ID de substância PubChem: 329749901
• NACRES: NA.24

Propriedades

• grau: pharmaceutical primary standard
• família API: flurbiprofen
• fabricante/nome comercial: USP
• pf: 110-112 °C (lit.)
• aplicação(ões): pharmaceutical (small molecule)
• formato: neat
• cadeia de caracteres SMILES: CC(C(O)=O)c1ccc(c(F)c1)-c2ccccc2
• InChI: 1S/C15H13FO2/c1-10(15(17)18)12-7-8-13(14(16)9-12)11-5-3-2-4-6-11/h2-10H,1H3,(H,17,18)
• chave InChI: SYTBZMRGLBWNTM-UHFFFAOYSA-N
• Informações sobre genes: human ... PTGS1(5742) , PTGS2(5743)

Descrição

Descrição geral

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.
For further information and support please go to the website of the issuing Pharmacopoeia.

Aplicação

Flurbiprofen USP reference standard, intended for use in specified quality tests and assays as specified in the USP compendia. Also, for use with USP monographs such as:

• Flurbiprofen Tablets
• Flurbiprofen Sodium
• Flurbiprofen Sodium Ophthalmic Solution

Ações bioquímicas/fisiológicas

Fluibiprofen is a cyclooxygenase (COX) inhibitor, which is an enzyme responsible for the conversion of arachidonic acid to prostaglandin G2 (PGG2) and PGG2 to prostaglandin H2 (PGH2) in the prostaglandin synthesis pathway. This decreases the prostaglandins which cause inflammation, pain, swelling and fever. Flurbiprofen inhibits the activity of both COX-1 and -2. The S enantiomer inhibits prostaglandin synthesis and has both anti-inflammatory and analgesic activity, while the R enantiomer does not inhibit prostaglandin synthesis and displays only analgesic activity.

Nota de análise

These products are for test and assay use only. They are not meant for administration to humans or animals and cannot be used to diagnose, treat, or cure diseases of any kind.  ​

Outras notas

Sales restrictions may apply.

Informações de segurança

• Pictogramas: GHS06
• Palavra indicadora: Danger
• Frases de perigo: H301
• Declarações de precaução: P264 - P270 - P301 + P310 - P405 - P501
• Classificações de perigo: Acute Tox. 3 Oral
• Código de classe de armazenamento: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• Classe de risco de água (WGK): WGK 3
• Ponto de fulgor (°F): Not applicable
• Ponto de fulgor (°C): Not applicable