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1249406

USP

Escitalopram oxalate

United States Pharmacopeia (USP) Reference Standard

Sinônimo(s):

S-(+)-1-[3-(Dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydro-5-isobenzofurancarbonitrile oxalate, S-(+)-Citalopram oxalate

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About This Item

Fórmula empírica (Notação de Hill):
C20H21FN2O · C2H2O4
Número CAS:
219861-08-2
Peso molecular:
414.43
Número MDL:
MFCD06407826
Código UNSPSC:
41116107
ID de substância PubChem:
329749746
NACRES:
NA.24

grau

pharmaceutical primary standard

família API

escitalopram, escitalopram

fabricante/nome comercial

USP

aplicação(ões)

pharmaceutical (small molecule)

Formato

neat

temperatura de armazenamento

2-8°C

cadeia de caracteres SMILES

OC(=O)C(O)=O.CN(C)CCC[C@]1(OCc2cc(ccc12)C#N)c3ccc(F)cc3

InChI

1S/C20H21FN2O.C2H2O4/c1-23(2)11-3-10-20(17-5-7-18(21)8-6-17)19-9-4-15(13-22)12-16(19)14-24-20;3-1(4)2(5)6/h4-9,12H,3,10-11,14H2,1-2H3;(H,3,4)(H,5,6)/t20-;/m0./s1

chave InChI

KTGRHKOEFSJQNS-BDQAORGHSA-N

Informações sobre genes

human ... SLC6A4(6532)

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Descrição geral

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the authority of the issuing pharmacopoeia. For further information and support please go to the website of the issuing Pharmacopoeia.

Escitalopram oxalate, the S-enantiomer of racemic citalopram, belongs to the class of compounds known as antidepressants, that works as a selective serotonin-reuptake inhibitor (SSRI).

Aplicação

Escitalopram oxalate USP reference standard, intended for use in specified quality tests and assays as specified in the USP compendia. Also, for use with USP monographs such as:
  • Escitalopram Oral Solution
  • Escitalopram Oxalate
  • Escitalopram Tablets

Ações bioquímicas/fisiológicas

Escitalopram is a selective serotonin reuptake inhibitor (SSRI), the S-enantiomer and eutomer of citalopram.

Nota de análise

These products are for test and assay use only. They are not meant for administration to humans or animals and cannot be used to diagnose, treat, or cure diseases of any kind.  ​

Outras notas

Sales restrictions may apply.

Pictogramas

Exclamation mark
GHS07

Palavra indicadora

Warning

Frases de perigo

H302 + H312

Classificações de perigo

Acute Tox. 4 Dermal - Acute Tox. 4 Oral

Código de classe de armazenamento

11 - Combustible Solids

Classe de risco de água (WGK)

WGK 3

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable

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Certificados de análise (COA)

Lot/Batch Number

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Spectrophotometric and reversed-phase high-performance liquid chromatographic methods for simultaneous determination of escitalopram oxalate and clonazepam in combined tablet dosage form
Gandhi VS, et al.
Journal of AOAC (Association of Official Analytical Chemists) International, 91(1), 33-38 (2008)
Dietmar Hestermann et al.
Behavioural brain research, 273, 155-165 (2014-07-22)
Serotonergic (5-HT) drugs are widely used in the clinical management of mood and anxiety disorders. However, it is reported that acute 5-HT treatment elicits anxiogenic-like behavior. Interestingly, the periaqueductal gray (PAG), a midbrain structure which regulates anxiety behavior - has
Kristan A Leech et al.
Journal of neurotrauma, 31(15), 1334-1342 (2014-04-20)
Incomplete spinal cord injury (iSCI) often results in significant motor impairments that lead to decreased functional mobility. Loss of descending serotonergic (5HT) input to spinal circuits is thought to contribute to motor impairments, with enhanced motor function demonstrated through augmentation
Simultaneous HPTLC determination of escitalopram oxalate and clonazepam in combined tablets.
Dhavale N, et al.
Chromatographia, 67(5-6), 487-490 (2008)
Gabriel Nowak et al.
Neuropharmacology, 84, 46-51 (2014-05-07)
Metabotropic glutamate 5 (mGlu5) receptors are functionally connected with NMDA receptors. The antidepressant activity of the NMDA receptor antagonist ketamine in both preclinical and clinical studies, along with the antidepressant-like activities of negative allosteric modulators (NAMs) of mGlu5, led us

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