Z2626
Zaragozic acid A trisodium salt
from microbial, ≥95% (HPLC), lyophilized powder, squalene synthase inhibitor
Sinônimo(s):
L-694,599, Squalestatin
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About This Item
Fórmula empírica (Notação de Hill):
C35H43O14Na3
Número CAS:
Peso molecular:
756.68
Número MDL:
Código UNSPSC:
12352106
NACRES:
NA.77
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Nome do produto
Zaragozic acid A trisodium salt, ≥95% (HPLC), microbial
fonte biológica
microbial
Nível de qualidade
Ensaio
≥95% (HPLC)
Formulário
lyophilized powder
solubilidade
DMSO: 9.80-10.20 mg/mL, clear, colorless to faintly yellow
Condições de expedição
wet ice
temperatura de armazenamento
−20°C
Aplicação
Zaragozic acid A trisodium salt has been used as:
- a component of serum-free medium for human embryonic kidney cells in a wound scratch assay to test its effect on wound healing
- a farnesyl-diphosphate farnesyltransferase 1 (FDFT1) or squalene synthase inhibitor in stromal cells
- a cholesterol synthesis inhibitor in T cells
Ações bioquímicas/fisiológicas
Potent inhibitor, in vivo and in vitro, of mammalian, fungal and Saccharomyces cervisiae squalene synthase. Squalene synthase is the first committed enzyme in sterol synthesis, catalyzing the reductive condensation of farnesyl pyrophosphate to form squalene. As a squalene synthase inhibitor, zaragozic acid produces lower plasma cholesterol levels in primates. Treatment of rats with zaragozic acid A caused an increase in hepatic low density lipoprotein (LDL) receptor mRNA levels.
Informações legais
Manufactured and sold under a restricted license from Merck & Co., Inc., Kenilworth, NJ, U.S.
Código de classe de armazenamento
11 - Combustible Solids
Classe de risco de água (WGK)
WGK 3
Ponto de fulgor (°F)
Not applicable
Ponto de fulgor (°C)
Not applicable
Equipamento de proteção individual
Eyeshields, Gloves, type N95 (US)
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