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Z0877

Sigma-Aldrich

Zotepine

Sinônimo(s):

2-[(8-chlorodibenzo[b,f]-thiepin-10-yl)oxy]-N,N-dimethylethanamine

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About This Item

Fórmula empírica (Notação de Hill):
C18H18ClNOS
Número CAS:
26615-21-4
Peso molecular:
331.86
Número MDL:
MFCD00868143
Código UNSPSC:
12352200
ID de substância PubChem:
329831602
NACRES:
NA.77

Ensaio

>98% (HPLC)

Nível de qualidade

100

forma

powder

cor

white to off-white

solubilidade

DMSO: ≥20 mg/mL

originador

Astellas

temperatura de armazenamento

room temp

cadeia de caracteres SMILES

CN(C)CCOC1=Cc2ccccc2Sc3ccc(Cl)cc13

InChI

1S/C18H18ClNOS/c1-20(2)9-10-21-16-11-13-5-3-4-6-17(13)22-18-8-7-14(19)12-15(16)18/h3-8,11-12H,9-10H2,1-2H3

chave InChI

HDOZVRUNCMBHFH-UHFFFAOYSA-N

Aplicação

Zotepine has been used as an anti-psychotic agent:
  • in biophysical studies with serotonin 2A receptor (5-HT2AR)
  • to study its effects on the inhibition of human organic cation transporter 1 (hOCT1)
  • to study its protective effects on the human embryonic kidney (HEK cells)

Ações bioquímicas/fisiológicas

Zotepine acts as an antagonist of dopamine D1, D2, and serotonin (5-HT2A/2C) receptors, and noradrenaline transporters. It shows therapeutic effects against schizophrenia and acute mania.
Zotepine is an atypical antipsychotic.

Características e benefícios

This compound is featured on the Dopamine Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
This compound was developed by Astellas. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Pictogramas

Exclamation markEnvironment
GHS07,GHS09

Palavra indicadora

Warning

Frases de perigo

H302,H410

Classificações de perigo

Acute Tox. 4 Oral - Aquatic Acute 1 - Aquatic Chronic 1

Código de classe de armazenamento

11 - Combustible Solids

Classe de risco de água (WGK)

WGK 3

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable

Certificados de análise (COA)

Busque Certificados de análise (COA) digitando o Número do Lote do produto. Os números de lote e remessa podem ser encontrados no rótulo de um produto após a palavra “Lot” ou “Batch”.

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Encontre a documentação dos produtos que você adquiriu recentemente na biblioteca de documentos.

Visite a Biblioteca de Documentos

Claudia Asenjo Lobos et al.
The Cochrane database of systematic reviews, (11)(11), CD006633-CD006633 (2010-11-12)
Clozapine is an atypical antipsychotic demonstrated to be superior in the treatment of refractory schizophrenia which causes fewer movement disorders. Clozapine, however, entails a significant risk of serious blood disorders such as agranulocytosis which could be potentially fatal. Currently there
Ching-Hua Lin et al.
Journal of clinical psychopharmacology, 32(6), 773-777 (2012-11-08)
Remission seems achievable for a portion of schizophrenic patients. This study aimed to identify the early predictors for remission and to establish an optimal prediction model. One hundred thirty-five acutely ill schizophrenic inpatients received 150-mg/d zotepine treatment for 4 weeks.
Katja Komossa et al.
The Cochrane database of systematic reviews, (1)(1), CD006628-CD006628 (2010-01-22)
In many countries of the industrialised world, second generation (atypical) antipsychotic drugs have become first line treatment for people with schizophrenia. The question as to whether the effects of various second generation antipsychotic drugs differ is a matter of debate.
Britta Haenisch et al.
Naunyn-Schmiedeberg's archives of pharmacology, 385(10), 1017-1023 (2012-07-19)
Besides the three antidepressant-sensitive, Na(+)- and Cl(-)-dependent monoamine transporters, Na(+)-independent organic cation transporters (OCTs) are known to transport monoamines. However, little is known about the interactions of psychotropic drugs with human (h) OCTs. In the present study, a series of
Kazuyoshi Nozaki et al.
Analytical sciences : the international journal of the Japan Society for Analytical Chemistry, 25(10), 1197-1201 (2009-10-14)
A simple, rapid, and sensitive on-line liquid chromatographic electrochemistry/electrospray/tandem mass spectrometry (LC-EC/ESI-MS/MS) method for the determination of zotepine in human serum was developed using a new generated-electrochemically fragment ion, and was validated. A recent novel technique of LC-EC/ESI-MS/MS that combines
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