T1783

Tobramycin sulfate salt

aminoglycoside antibiotic

• Sinônimo(s): Nebramycin Factor 6 sulfate
• Fórmula empírica (Notação de Hill): C₁₈H₃₇N₅O₉ · xH₂SO₄
• Peso molecular: 467.51 (free base basis)
• Número MDL: MFCD00133864
• Código UNSPSC: 51281677
• ID de substância PubChem: 329826686
• NACRES: NA.85

Propriedades

• fonte biológica: Streptomyces tenebrarius
• Nível de qualidade: 200
• Formulário: powder
• potência: 634-739 μg per mg
• condição de armazenamento: (Keep container tightly closed in a dry and well-ventilated place. Hygroscopic.)
• cor: white to off-white
• solubilidade: H₂O: soluble 50 mg/mL
• espectro de atividade do antibiótico: Gram-negative bacteria
• Modo de ação: protein synthesis | interferes
• temperatura de armazenamento: 2-8°C
• cadeia de caracteres SMILES: OS(O)(=O)=O.NC[C@H]1O[C@H](O[C@@H]2[C@@H](N)C[C@@H](N)[C@H](O[C@H]3O[C@H](CO)[C@@H](O)[C@H](N)[C@H]3O)[C@H]2O)[C@H](N)C[C@@H]1O
• InChI: 1S/C18H37N5O9.H2O4S/c19-3-9-8(25)2-7(22)17(29-9)31-15-5(20)1-6(21)16(14(15)28)32-18-13(27)11(23)12(26)10(4-24)30-18;1-5(2,3)4/h5-18,24-28H,1-4,19-23H2;(H2,1,2,3,4)/t5-,6+,7+,8-,9+,10+,11-,12+,13+,14-,15+,16-,17+,18+;/m0./s1
• chave InChI: ZEUUPKVZFKBXPW-TWDWGCDDSA-N

Descrição

Descrição geral

Chemical structure: aminoglycoside

Aplicação

Tobramycin is an aminoglycoside, broad-spectrum antibiotic produced by Streptomyces tenebrarius. It is effective against gram-negative bacteria, especially the pseudomonas species. It is not effective against Enterococci. It is used to inhibit bacterial protein synthesis at the level of 30S (16S rRNA) and 70S ribosomal complex assembly. It is used to treat pseudomonas aeruginosa lung infections and is used in combination with other antibiotics to treat urinary tract infections, gynecologic infections, peritonitis, endocarditis, pneumonia, sepsis, respiratory infections, osteomyelitis and other soft-tissue infections. It is a potential therapy for sinus infections. Product T1783 has been used to study antibiotic resistance.

Ações bioquímicas/fisiológicas

Tobramycin binds irreversibly to one of two aminoglycoside binding sites on the 30 S ribosomal subunit, inhibiting bacterial protein synthesis. Tobramycin may also destabilize bacterial membranes by binding to 16 S r-RNA. It inhibits translocation and elicits miscoding. Tobramycin binds to an RNA aptamer, which is structurally similar to the A site of 16S rRNA.

Tobramycin sulfate is an aminoglycoside.
Mode of Action: Binds to 70S ribosomal subunit; inhibits translocation; elicits miscoding.
Spectrum of Activity: Gram negative bacteria. Not effective against Enterococci.

Embalagem

100MG,500MG

Atenção

Hygroscopic

Outras notas

Keep container tightly closed in a dry and well-ventilated place. Hygroscopic.

Informações de segurança

• Pictogramas: GHS08,GHS07
• Palavra indicadora: Danger
• Frases de perigo: H312 + H332,H360
• Declarações de precaução: P202 - P261 - P280 - P302 + P352 + P312 - P304 + P340 + P312 - P308 + P313
• Classificações de perigo: Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Repr. 1B
• Código de classe de armazenamento: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• Classe de risco de água (WGK): WGK 3
• Ponto de fulgor (°F): Not applicable
• Ponto de fulgor (°C): Not applicable
• Equipamento de proteção individual: Eyeshields, Gloves, type P3 (EN 143) respirator cartridges