Pular para o conteúdo
Merck
Todas as fotos(1)

Key Documents

SRP8056

Sigma-Aldrich

Tim-3 (mouse): FC (human)

recombinant, expressed in CHO cells, ≥98% (SDS-PAGE)

Sinônimo(s):

HAVcr-2, T-cell immunoglobulin and mucin domain-containing protein 3, TIM3, TIMD3

Faça loginpara ver os preços organizacionais e de contrato


About This Item

Código UNSPSC:
12352200
NACRES:
NA.32

fonte biológica

mouse

recombinante

expressed in CHO cells

Ensaio

≥98% (SDS-PAGE)

forma

lyophilized

peso molecular

monomer 45 kDa by calculation

embalagem

pkg of 100 μg

condição de armazenamento

avoid repeated freeze/thaw cycles

Impurezas

<0.06 EU/μg endotoxin, tested

cor

white

nº de adesão UniProt

Condições de expedição

wet ice

temperatura de armazenamento

−20°C

Informações sobre genes

mouse ... Havcr2(171285)

Descrição geral

Tim-3 is a type I transmembrane protein. It contains an immunoglobulin and a mucin-like domain in its extracellular portion and a tyrosine phosphorylation motif in its cytoplasmic portion. TIM-3 is preferentially expressed on Type 1 T-helper (Th1) and Type 1 CD8+ T (Tc1) cells. TIM-3 is also expressed on some dendritic cells. The gene encoding this protein is localized on mouse chromosome 11B1.1.

Ações bioquímicas/fisiológicas

The T cell/transmembrane, immunoglobulin and mucin (TIM) family plays a crucial role in regulating immune responses, such as allergy, asthma, transplant tolerance, autoimmunity and also has a control over the response to viral infections. The unique structure of TIM immunoglobulin variable region domains allows highly specific recognition of phosphatidylserine (PtdSer), exposed on the surface of apoptotic cells. Tim-3 generates an inhibitory signal resulting in apoptosis of Type 1 T-helper (Th1) and Type 1 CD8+ T (Tc1) cells. It can also mediate phagocytosis of apoptotic cells and cross-presentation of antigen. It functions to inhibit aggressive Th1-mediated auto- and allo-immune responses. Tim-3 pathway blockade by administration of Tim-3: Fc fusion protein accelerates diabetes in non-obese diabetic mice, causes hyperproliferation of Th1 cells and Th1 cytokine release in an experimental autoimmune encephalomyelitis (EAE) model and prevents acquisition of transplantation tolerance induced by costimulation blockade.

forma física

Lyophilized from 0.2 μm-filtered solution in PBS.

Reconstituição

Reconstitute at 100 μg/mL in sterile PBS.

Outras notas

The extracellular domain of mouse Tim-3 (aa 21-189) is fused to the N-terminus of the Fc region of human IgG1.

Código de classe de armazenamento

10 - Combustible liquids

Classe de risco de água (WGK)

WGK 2

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable


Certificados de análise (COA)

Busque Certificados de análise (COA) digitando o Número do Lote do produto. Os números de lote e remessa podem ser encontrados no rótulo de um produto após a palavra “Lot” ou “Batch”.

Já possui este produto?

Encontre a documentação dos produtos que você adquiriu recentemente na biblioteca de documentos.

Visite a Biblioteca de Documentos

TIM-3 is Expressed on Activated Human CD4+ T Cells and Regulates Th1 and Th17 Cytokines
William D. Hastings
European Journal of Immunology, 39(9), 2492-2501 (2009)
TIM Proteins and Immunity
Lawrence P. Kane
Journal of Immunology, 184(6), 2743-2749 (2010)
T and B cell hyperactivity and autoimmunity associated with niche-specific defects in apoptotic body clearance in TIM-4-deficient mice
Roselyn R
Proceedings of the National Academy of Sciences of the USA, 107.19, 8706-8711 (2010)
TIM-1 and TIM-3 Proteins in Immune Regulation
Ee Wern Su
Cytokine, 44(1), 9-13 (2008)
TIM genes: a family of cell surface phosphatidylserine receptors that regulate innate and adaptive immunity
Gordon J. Freeman
Immunological Reviews, 235(1), 172-189 (2010)

Nossa equipe de cientistas tem experiência em todas as áreas de pesquisa, incluindo Life Sciences, ciência de materiais, síntese química, cromatografia, química analítica e muitas outras.

Entre em contato com a assistência técnica