SRP6282

Nicotinamide N-Methyltransferase (hNNMT) human

recombinant, expressed in E. coli, ≥98% (SDS-PAGE)

• Sinônimo(s): NNMT
• Código UNSPSC: 12352204
• NACRES: NA.32

Propriedades

• fonte biológica: human
• recombinante: expressed in E. coli
• Ensaio: ≥98% (SDS-PAGE)
• Formulário: liquid
• peso molecular: 31.7 kDa (263 aa + NT 6xHis-tag)
• embalagem: pkg of 1 mg; pkg of 100 μg; pkg of 20 μg
• concentração: 3.42 mg/mL
• nº de adesão UniProt: P40261
• Condições de expedição: dry ice
• temperatura de armazenamento: −70°C
• Informações sobre genes: human ... NNMT(4837)

Descrição

Descrição geral

N-methylation is one method by which drug and other xenobiotic compounds are metabolized by the liver. NNMT is an important cytosolic methyltransferase catalyzing the N-methylation of nicotinamide, pyridines and structural analogs, playing a crucial role in the biotransformation and detoxification of many xenobiotic compounds. In the N-methylation process, NNMT uses S-adenosyl methionine as the methyl donor and nicotinamide as methyl acceptor. NNMT is mostly expressed in the liver, and a lower expression is seen in the kidney, lung, skeletal muscle, placenta and heart. It may also play an important role in regulating biological processes related to N-methyl nicotinamide such as anti-inflammatory, anti-thrombotic, vasoprotective, and gastroprotective properties. Increased NNMT activity was reported in many kinds of tumors. NNMT is a potential biomarker and therapeutic target in caner diagnosis and treatment. NNMT serum levels have significance in the premature detection and in the management of patients with colorectal cancer. The recombinant protein includes hNNMT with N-terminal His-tag.

forma física

3.42 mg/mL solution in 25 mM Tris (pH8.0) buffer containing 20% glycerol.

Informações de segurança

• Código de classe de armazenamento: 13 - Non Combustible Solids
• Classe de risco de água (WGK): WGK 3
• Ponto de fulgor (°F): Not applicable
• Ponto de fulgor (°C): Not applicable