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SRP5219

Sigma-Aldrich

KAT3A (518-1207), GST tagged human

recombinant, expressed in baculovirus infected Sf9 cells, ≥70% (SDS-PAGE), buffered aqueous glycerol solution

Sinônimo(s):

CBP, CREBBP, KAT3A, RSTS

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About This Item

Número CAS:
2226029-28-1
Código UNSPSC:
12352200
NACRES:
NA.32

fonte biológica

human

recombinante

expressed in baculovirus infected Sf9 cells

Ensaio

≥70% (SDS-PAGE)

forma

buffered aqueous glycerol solution

peso molecular

~140 kDa

nº de adesão NCBI

NM_004380

aplicação(ões)

cell analysis

Condições de expedição

dry ice

temperatura de armazenamento

−70°C

Informações sobre genes

human ... CREBBP(1387)

Ações bioquímicas/fisiológicas

KAT3A has intrinsic histone acetyltransferase activity that acts as a scaffold to stabilize additional protein interactions with the transcription complex and acetylates both histone and non-histone proteins. KAT3A (CREBBP) expressed as a nuclear protein that binds to cAMP-response element binding protein (CREB) and involved in the transcriptional coactivation of many different transcription factors. KAT3A plays a main role in embryonic development, growth control, and homeostasis by coupling chromatin remodeling to transcription factor recognition. KAT3A also plays a critical role in the transmission of inductive signals from cell surface receptors to the transcriptional apparatus.

forma física

Supplied in 50mM Tris-HCl, pH 7.5, 150mM NaCl, 10mM glutathione, 0.1mM EDTA, 0.25mM DTT, 0.1mM PMSF, 25% glycerol.

Nota de preparo

after opening, aliquot into smaller quantities and store at -70 °C. Avoid repeating handling and multiple freeze/thaw cycles

Código de classe de armazenamento

10 - Combustible liquids

Classe de risco de água (WGK)

WGK 1

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Lawryn H Kasper et al.
Nature, 419(6908), 738-743 (2002-10-18)
The coactivators CBP (Cre-element binding protein (CREB)-binding protein) and its paralogue p300 are thought to supply adaptor molecule and protein acetyltransferase functions to many transcription factors that regulate gene expression. Normal development requires CBP and p300, and mutations in these
J Arias et al.
Nature, 370(6486), 226-229 (1994-07-21)
A number of signalling pathways stimulate transcription of target genes through nuclear factors whose activities are primarily regulated by phosphorylation. Cyclic AMP regulates the expression of numerous genes, for example, through the protein kinase-A (PKA)-mediated phosphorylation of transcription factor CREB

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