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SRP3275

Sigma-Aldrich

IL-33 human

Animal-component free, ≥98% (SDS-PAGE & HPLC), recombinant, expressed in E. coli, lyophilized

Sinônimo(s):

NF-HEV

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About This Item

Código UNSPSC:
12352202
NACRES:
NA.32

Nome do produto

IL-33 human, Animal-component free, recombinant, expressed in E. coli, ≥98% (SDS-PAGE), ≥98% (HPLC)

fonte biológica

human

recombinante

expressed in E. coli

Ensaio

≥98% (HPLC)
≥98% (SDS-PAGE)

Formulário

lyophilized

potência

≥0.05 ng/mL ED50

peso molecular

17.9 kDa

embalagem

pkg of 10 μg

Impurezas

<0.1 EU/μg endotoxin, tested

cor

white to off-white

nº de adesão UniProt

O95760

Condições de expedição

wet ice

temperatura de armazenamento

−20°C

Informações sobre genes

human ... IL33(90865)

Categorias relacionadas

Descrição geral

It binds and signals through the IL-1RL1/ST2 receptor activating NF-kappaB and MAP kinases. IL-33 induces production of TH2 cell related cytokines, including IL-4, IL-5 and IL-13, and exerts multiple inflammation related bioactivities.

Ações bioquímicas/fisiológicas

Human IL-33 is a proinflammatory protein that shares structural and functional characteristics with the IL-1 cytokine family. Recombinant human IL-33 is a 17.9 kDa protein containing 159 amino acid residues.

forma física

Lyophilized from 10 mM Sodium Phosphate, pH 8.0 + 0.5 mM DTT.

Reconstituição

Centrifuge the vial prior to opening. Reconstitute in water to a concentration of 0.1-1.0 mg/mL. Do not vortex. This solution can be stored at 2-8°C for up to 1 week. For extended storage, it is recommended to further dilute in a buffer containing a carrier protein (example 0.1% BSA) and store in working aliquots at -20°C to -80°C.

Código de classe de armazenamento

10 - Combustible liquids

Classe de risco de água (WGK)

WGK 1

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable

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Certificados de análise (COA)

Lot/Batch Number
0512AFC398

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Ying Lei et al.
PloS one, 10(7), e0133774-e0133774 (2015-07-28)
In several clinical and experimental studies IL-33 and its receptor have been found to play important roles in the development of asthma and allergic airway inflammation. We evaluated the effects of vaccination against IL-33 in a mouse model of airway
Elizabeth A Oczypok et al.
The Journal of allergy and clinical immunology, 136(3), 747-756 (2015-05-02)
Single nucleotide polymorphisms in the human gene for the receptor for advanced glycation end-products (RAGE) are associated with an increased incidence of asthma. RAGE is highly expressed in the lung and has been reported to play a vital role in
Jochen Schmitz et al.
Immunity, 23(5), 479-490 (2005-11-16)
Cytokines of the interleukin-1 (IL-1) family, such as IL-1 alpha/beta and IL-18, have important functions in host defense, immune regulation, and inflammation. Insight into their biological functions has led to novel therapeutic approaches to treat human inflammatory diseases. Within the
Rebecca L Maywald et al.
Proceedings of the National Academy of Sciences of the United States of America, 112(19), E2487-E2496 (2015-04-29)
Tumor epithelial cells develop within a microenvironment consisting of extracellular matrix, growth factors, and cytokines produced by nonepithelial stromal cells. In response to paracrine signals from tumor epithelia, stromal cells modify the microenvironment to promote tumor growth and metastasis. Here
Xi-Xiang Yu et al.
Digestive diseases and sciences, 60(5), 1265-1272 (2015-02-07)
As a pro-inflammatory cytokine, IL-33 has been demonstrated to play an important role in tumor progression. It is reported that IL-33 is highly expressed in the serum and tumor tissues of patients with gastric cancer. However, the function of IL-33
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