SRP3241

IL-13 Long Form from rat

≥98% (SDS-PAGE & HPLC), recombinant, expressed in E. coli, lyophilized, suitable for cell culture

• Sinônimo(s): NC300 (Human) P600 (Murine), interleukin 13
• Código UNSPSC: 12352202
• NACRES: NA.32

Propriedades

• product name: IL-13 Long Form from rat, recombinant, expressed in E. coli, ≥98% (SDS-PAGE), ≥98% (HPLC), suitable for cell culture
• fonte biológica: rat
• recombinante: expressed in E. coli
• Ensaio: ≥98% (HPLC); ≥98% (SDS-PAGE)
• forma: lyophilized
• potência: ≤5.0 ng/mL ED₅₀
• peso molecular: 12.3 kDa
• embalagem: pkg of 10 μg
• técnica(s): cell culture | mammalian: suitable
• Impurezas: <0.1 EU/μg endotoxin, tested
• cor: white to off-white
• nº de adesão UniProt: P42203
• Condições de expedição: wet ice
• temperatura de armazenamento: −20°C
• Informações sobre genes: rat ... IL13(116553)

Descrição

Descrição geral

IL13 (interleukin 13) is a classic cytokine produced by Th2 (T-helper) cells. It was originally identified as an inflammatory cytokine production-inhibiting T-cell derived cytokine.
Human and murine IL-13 is cross-species reactive. Recombinant rat IL-13 is a 11.9kDa protein consisting of 109 amino acid residues.

Ações bioquímicas/fisiológicas

IL13 (interleukin 13) is up-regulated during parasitic infections, and participates in host′s protective immunity against Schistosoma japonicum. This protein promotes eosinophil activation resulting in elevated specific IgE against adult and larval antigens. During acute infection it promotes egg expulsion through increased intestinal contractility. It acts as a liver protective agent where it promotes formation of liver granulomas in a CD4⁺ T cell-mediated manner, which results in liver fibrosis. In airway disorders, such as asthma, chronic obstructive pulmonary disease (COPD), and cystic fibrosis lung disease, IL13 promotes the formation of airway goblet cells, resulting in excess mucus secretion, which in turn, is regulated by IL13-activated autophagy.

Sequência

TPGPVRRSTS PPVALRELIE ELSNITQDQK TSLCNSSIVW SVDLTAGGFC AALESLTNIS SCNAIHRTQR ILNGLCNQKA SDVASSPPDT KIEVAQFISK LLNYSKQLFR YGH

forma física

Lyophilized with no additives.

Reconstituição

Centrifuge the vial prior to opening. Reconstitute in water to a concentration of 0.1-1.0 mg/ml. Do not vortex. This solution can be stored at 2-8°C for up to 1 week. For extended storage, it is recommended to further dilute in a buffer containing a carrier protein (example 0.1% BSA) and store in working aliquots at -20°C to -80°C.

Informações de segurança

• Código de classe de armazenamento: 11 - Combustible Solids
• Classe de risco de água (WGK): WGK 3
• Ponto de fulgor (°F): Not applicable
• Ponto de fulgor (°C): Not applicable