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Documentos Principais

SRP2080

Sigma-Aldrich

BRCA1 human

recombinant, expressed in insect cells, ≥70% (SDS-PAGE)

Sinônimo(s):

BRCAI, BRCC1, BROVCA1, IRIS, PNCA4, PSCP, RNF53

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About This Item

Código UNSPSC:
12352200
NACRES:
NA.26

fonte biológica

human

recombinante

expressed in insect cells

Ensaio

≥70% (SDS-PAGE)

Formulário

frozen liquid

peso molecular

~209 kDa

embalagem

pkg of 20 μg

condição de armazenamento

avoid repeated freeze/thaw cycles

concentração

350 μg/mL

cor

clear
 colorless

nº de adesão NCBI

NM_007296

nº de adesão UniProt

P38398

Condições de expedição

dry ice

temperatura de armazenamento

−70°C

Informações sobre genes

human ... BRCA1(672)

Ações bioquímicas/fisiológicas

The human BRCA1, the product of breast and ovarian cancer gene 1, is a hyperphosphorylated protein functioning as a tumor suppressor involved in both transcription regulation and DNA repair. BRCA1 associates with RAD51 and has shown to be required for transcription-coupled repair of DNA damage as well as for the repair of chromosomal double-strand breaks. Association with a human SWI/SNF-related complex has recently suggested a potential role of BRCA1 in linking chromatin remodeling to breast cancer.

forma física

Clear and colorless frozen liquid solution

Nota de preparo

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. While working, please keep sample on ice.

Código de classe de armazenamento

10 - Combustible liquids

Classe de risco de água (WGK)

WGK 1

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable

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Certificados de análise (COA)

Lot/Batch Number
63028149
093014043

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Corinne Chabalier-Taste et al.
Oncotarget, 7(3), 2269-2283 (2016-01-09)
Accurate repair of DNA double-strand breaks (DSB) caused during DNA replication and by exogenous stresses is critical for the maintenance of genomic integrity. There is growing evidence that the Polo-like kinase 1 (Plk1) that plays a number of pivotal roles
E Maldonado et al.
Nature, 381(6577), 86-89 (1996-05-02)
We report here the isolation of a human RNA polymerase II complex containing a subset of the basal transcription factors and the human homologues of the yeast SRB (for suppressors of RNA polymerase B) proteins. The complex contains transcriptional coactivators
R Scully et al.
Proceedings of the National Academy of Sciences of the United States of America, 94(11), 5605-5610 (1997-05-27)
The familial breast-ovarian tumor suppressor gene product BRCA1 was found to be a component of the RNA polymerase II holoenzyme by several criteria. BRCA1 was found to copurify with the holoenzyme over multiple chromatographic steps. Other tested transcription activators that
S K Sharan et al.
Nature, 386(6627), 804-810 (1997-04-24)
Inherited mutations in the human BRCA2 gene cause about half of the cases of early-onset breast cancer. The embryonic expression pattern of the mouse Brca2 gene is now defined and an interaction identified of the Brca2 protein with the DNA-repair

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