SRP0293
Cathepsin V Active human
recombinant, expressed in FreeStyle™ 293-F cells, ≥90% (SDS-PAGE)
Sinônimo(s):
Cathepsin L2, Cathepsin U
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About This Item
Código UNSPSC:
12352204
NACRES:
NA.54
Produtos recomendados
recombinante
expressed in FreeStyle™ 293-F cells
Ensaio
≥90% (SDS-PAGE)
Formulário
aqueous solution
atividade específica
≥436 pmol/min-μg
peso molecular
37 kDa
nº de adesão NCBI
Condições de expedição
dry ice
temperatura de armazenamento
−70°C
Informações sobre genes
human ... CTSL2(1515)
Descrição geral
Human cathepsin V (GenBank Accession No. NM_001333.2), CD33 signal peptide(amino acids 1-16) + cathepsin V (amino acids 18-334), with C-terminal HIS tag, MW = 37 kDa, expressed in FreeStyle 293-F cells.
Aplicação
Active human cathepsin V is useful for the study of enzyme kinetics, screening inhibitors, and selectivity profiling. Active human cathepsin V has been used in a study to assess the cysteine protease attribute of the eukaryotic ribosomal protein S4. Active human cathepsin V has also been used in a study to determine that the simultaneous treatment of human bronchial epithelial cells with serine and cysteine protease inhibitors prevents severe acute respiratory syndrome coronavirus entry.
Definição da unidade
One unit is defined as the amount of enzyme that will cleave 1 pmol of substrate per min at 37°C
forma física
Formulated in 40 mM MES, pH 5.0, 120 mM NaCL and 20% glycerol.
Nota de preparo
Thaw on ice. Upon first thaw, briefly spin tube containing enzyme to recover full content of the tube. Aliquot enzyme into single use aliquots. Store remaining undiluted enzyme in aliquots at -70°C. Note: Enzyme is very sensitive to freeze/thaw cycles.
Informações legais
FreeStyle is a trademark of Invitrogen Corp.
Palavra indicadora
Danger
Frases de perigo
Declarações de precaução
Classificações de perigo
Eye Irrit. 2 - Repr. 1B - Skin Irrit. 2
Código de classe de armazenamento
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
Classe de risco de água (WGK)
WGK 1
Ponto de fulgor (°F)
Not applicable
Ponto de fulgor (°C)
Not applicable
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Babu Sudhamalla et al.
Biochimica et biophysica acta, 1820(10), 1535-1542 (2012-05-15)
Ribosomal proteins often carry out extraribosomal functions. The protein S4 from the smaller subunit of Escherichia coli, for instance, regulates self synthesis and acts as a transcription factor. In humans, S4 might be involved in Turner syndrome. Recent studies also
Miyuki Kawase et al.
Journal of virology, 86(12), 6537-6545 (2012-04-13)
The type II transmembrane protease TMPRSS2 activates the spike (S) protein of severe acute respiratory syndrome coronavirus (SARS-CoV) on the cell surface following receptor binding during viral entry into cells. In the absence of TMPRSS2, SARS-CoV achieves cell entry via
Uta Schurigt et al.
Inflammation research : official journal of the European Histamine Research Society ... [et al.], 61(9), 1021-1029 (2012-06-08)
Cathepsin L (CL) is potentially involved in joint destruction and in antigen presentation in rheumatoid arthritis. In order to define the roles of this protease in arthritis development we analysed the antigen-induced arthritis (AIA) in CL-deficient (CL(-/-)) mice. Antigen-induced arthritis
Ryan P McGlinchey et al.
Biochemical and biophysical research communications, 529(4), 1106-1111 (2020-08-21)
The intracellular accumulation of α-synuclein (α-syn) amyloid fibrils is a hallmark of Parkinson's disease. Because lysosomes are responsible for degrading aggregated species, enhancing lysosomal function could alleviate the overburden of α-syn. Previously, we showed that cysteine cathepsins (Cts) is the
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