SML3389

Vilanterol trifenatate

≥95% (HPLC)

• Sinônimo(s): 4-[(1R)-2-({6-[(2-{[(2,6-Dichlorophenyl)methyl]oxy}ethyl)oxy]-hexyl}-amino)-1-hydroxyethyl]-2-(hydroxymethyl)phenol, triphenylacetate salt, GW 642444 trifenatate, GW 642444M, GW-642444 trifenatate, GW-642444M, GW642444 trifenatate, GW642444M, Vilanterol triphenylacetate sal
• Fórmula empírica (Notação de Hill): C₂₄H₃₃Cl₂NO₅·C₂₀H₁₆O₂
• Número CAS: 503070-58-4
• Peso molecular: 774.77
• Número MDL: MFCD21362970
• Código UNSPSC: 12352200
• NACRES: NA.77

Propriedades

• Nível de qualidade: 100
• Ensaio: ≥95% (HPLC)
• Formulário: powder
• condição de armazenamento: desiccated
• cor: white to beige
• solubilidade: DMSO: 2 mg/mL, clear
• temperatura de armazenamento: −20°C
• cadeia de caracteres SMILES: OC(C(C1=CC=CC=C1)(C2=CC=CC=C2)C3=CC=CC=C3)=O.ClC(C=CC=C4Cl)=C4COCCOCCCCCCNC[C@@H](C5=CC(CO)=C(C=C5)O)O
• InChI: 1S/C24H33Cl2NO5.C20H16O2/c25-21-6-5-7-22(26)20(21)17-32-13-12-31-11-4-2-1-3-10-27-15-24(30)18-8-9-23(29)19(14-18)16-28;21-19(22)20(16-10-4-1-5-11-16,17-12-6-2-7-13-17)18-14-8-3-9-15-18/h5-9,14,24,27-30H,1-4,10-13,15-17H2;1-15H,(H,21,22)/t24-;/m0./s1
• chave InChI: KLOLZALDXGTNQE-JIDHJSLPSA-N

Descrição

Descrição geral

Vilanterol trifenatate is a potent and selective beta2 (β2)-adrenoceptor agonist. This bioactive small molecule has been shown to stimulate cellular cAMP accumulation in CHO cells that express human beta2 adrenoceptors, while not having the same effect on beta1 or beta3 receptors (pEC50 = 9.4/β2, 6.4/β1, 6.1/β3). Vilanterol can reduce the contraction of electrically stimulated guinea pig trachea strips and exhibits in vivo therapeutic efficacy in an asthma model in guinea pigs with histamine-induced bronchospasm (EC90 = nebulizer concentration 30 μM). Additionally, Vilanterol trifenatate acts as a substrate for P-glycoprotein (PgP).

Ações bioquímicas/fisiológicas

Vilanterol is a potent and selective, beta2 (β2)-adrenoceptor agonist that stimulates cellular cAMP accumulation in CHO cells expressing human beta2, but not beta1 or beta3, adrenoceptor (pEC50 = 9.4/β2, 6.4/β1, 6.1/β3). Vilanterol inhibits the contraction of electrically stimulated guinea pig trachea strips and displays in vivo therapeutic efficacy in a guinea pig asthma model of histamine-induced bronchospasm (EC90 = nebulizer concentration 30 μM).

Informações de segurança

• Pictogramas: GHS08,GHS07,GHS09
• Palavra indicadora: Warning
• Frases de perigo: H302,H315,H371,H411
• Declarações de precaução: P260 - P264 - P273 - P301 + P312 - P302 + P352 - P308 + P311
• Classificações de perigo: Acute Tox. 4 Oral - Aquatic Chronic 2 - Skin Irrit. 2 - STOT SE 2
• Órgãos-alvo: Cardiovascular
• Código de classe de armazenamento: 11 - Combustible Solids
• Classe de risco de água (WGK): WGK 3
• Ponto de fulgor (°F): Not applicable
• Ponto de fulgor (°C): Not applicable