SML3340

Sgl1 inhibitor Hit 1

≥98% (HPLC)

• Sinônimo(s): 4-Hydroxy-1-[[2-(3-methoxyphenyl)-5-thiazolyl]methyl]-4-piperidinemethanol
• Fórmula empírica (Notação de Hill): C₁₇H₂₂N₂O₃S
• Número CAS: 1332191-15-7
• Peso molecular: 334.43
• Código UNSPSC: 12352200
• NACRES: NA.77

Propriedades

• Nível de qualidade: 100
• Ensaio: ≥98% (HPLC)
• Formulário: powder
• cor: white to beige
• solubilidade: DMSO: 2 mg/mL, clear
• temperatura de armazenamento: 2-8°C
• cadeia de caracteres SMILES: COC1=CC=CC(C2=NC=C(S2)CN3CCC(O)(CC3)CO)=C1
• chave InChI: FXCZNKJONOHACS-UHFFFAOYSA-N

Descrição

Ações bioquímicas/fisiológicas

Cell penetrant, potent and low toxic inhibitor of Cryptococcus neoformans sterylglucosidase 1 (Sgl1)

Sgl1 inhibitor Hit 1 is a cell penetrant, potent and low toxic inhibitor of Cryptococcus neoformans sterylglucosidase 1 (Sgl1) that significantly increases in the intracellular concentration of ergosterol 3β-D-glucoside (erg-glc). Sgl1 inhibitor Hit 1 potently inhibits growth of wild-type C. neoformans. Also, it inhibits brain dissemination of C. neoformans in a mouse model of infection.

Informações de segurança

• Código de classe de armazenamento: 11 - Combustible Solids
• Classe de risco de água (WGK): WGK 3
• Ponto de fulgor (°F): Not applicable
• Ponto de fulgor (°C): Not applicable