SML2812

AN1

≥98% (HPLC)

• Sinônimo(s): 5-Bromo-3-[(3-bromo-4,5-dihydroxyphenyl)methylene]-1,3-dihydro-2H-indol-2-one, mHTT-LC3 linker AN1
• Fórmula empírica (Notação de Hill): C₁₅H₉Br₂NO₃
• Número CAS: 486443-73-6
• Peso molecular: 411.04
• Código UNSPSC: 12352200
• NACRES: NA.77

Propriedades

• Nível de qualidade: 100
• Ensaio: ≥98% (HPLC)
• Formulário: powder
• cor: white to beige
• solubilidade: DMSO: 2 mg/mL, clear
• temperatura de armazenamento: 2-8°C
• cadeia de caracteres SMILES: Brc1c(c(cc(c1)C=C2c3c(ccc(c3)Br)NC2=O)O)O
• InChI: 1S/C15H9Br2NO3/c16-8-1-2-12-9(6-8)10(15(21)18-12)3-7-4-11(17)14(20)13(19)5-7/h1-6,19-20H,(H,18,21)
• chave InChI: GPKLWRHHVIBYEO-UHFFFAOYSA-N

Descrição

Ações bioquímicas/fisiológicas

AN1 is a brain blood barrier penetrant agent that tether LC3 and mHTT and targets mHTT for autophagosome degradation. AN1 significantly lower mHTT in cortices of HD mice, in cells from patients with Huntington′s disease, and neurons derived from induced pluripotent stem cells. AN1 does not lower wtHTT in fibroblasts from healthy human donors. It appears that AN1 interact with the polyQ stretch.

brain blood barrier penetrant agent that tether LC3 and mHTT and targets mHTT for autophagosome degradation

Informações de segurança

• Código de classe de armazenamento: 11 - Combustible Solids
• Classe de risco de água (WGK): WGK 3
• Ponto de fulgor (°F): Not applicable
• Ponto de fulgor (°C): Not applicable