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SML2304

Sigma-Aldrich

Clozapine N-oxide hydrochloride

≥98% (HPLC), powder, muscarinic DREADD activator

Sinônimo(s):

Clozapine N-oxide hydrochloride, 8-Chloro-11-(4-methyl-1-piperazinyl)-5H-dibenzo[b,e](1,4)diazepine N-oxide, hydrochloride salt

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About This Item

Fórmula empírica (Notação de Hill):
C18H19ClN4O · xHCl
Número CAS:
34233-69-7
Peso molecular:
342.82 (free base basis)
Código UNSPSC:
12352119
NACRES:
NA.77

product name

Clozapine N-oxide hydrochloride, ≥98% (HPLC), Water soluble Clozapine N-oxide

fonte biológica

synthetic

Ensaio

≥98% (HPLC)

forma

powder

condição de armazenamento

desiccated

solubilidade

DMSO: 40 mg/mL
water: 40 mg/mL

Condições de expedição

ambient

temperatura de armazenamento

2-8°C

cadeia de caracteres SMILES

ClC1=CC2=C(NC(C=CC=C3)=C3C(N4CC[N+]([O-])(C)CC4)=N2)C=C1.[xHCl]

InChI

1S/C18H19ClN4O/c1-23(24)10-8-22(9-11-23)18-14-4-2-3-5-15(14)20-16-7-6-13(19)12-17(16)21-18/h2-7,12,20H,8-11H2,1H3

chave InChI

OGUCZBIQSYYWEF-UHFFFAOYSA-N

Descrição geral

Clozapine N-oxide hydrochloride is a water soluble form of Clozapine N-oxide (CNO) (Sigma cat# C0832). CNO is a pharmacologically inert metabolite of the atypical anti-psychotic drug clozapine. CNO is a ligand for the engineered Gq protein coupled receptors (GPCRs) in the chemogenetic Designer Receptors Exclusively Activated by Designer Drug (DREADD). The typical use of DREADD is testing, enhancing neuronal firing and activating Gq signaling in neuronal and non-neuronal cells.

The selective targeting of DREADD systems to cell population can be achieved by using a cell type-specific promoter to drive DREADD expression, and the expression of this promoter can be further controlled using a recombinase-based system. DREADDs possess a low affinity for endogenous ligands and little constitutive activity, but may be activated by synthetic compounds such as CNO.

DREADD systems are activated by low nM concentrations of CNO and mobilize intracellular calcium. CNO appears to be pharmacologically and behaviorally inert in mice and rats when administered at the recommended doses (generally 0.1–3 mg/kg). CNO is commonly administrated via injection but also can be mixed into food chow or drinking water.

Outras notas

High concentration Solutions of (40mg/ml) can be prepared from the water soluble CNO and be used in CNO applications without the use of DMSO.

Pictogramas

Skull and crossbones
GHS06

Palavra indicadora

Danger

Frases de perigo

H301,H336

Classificações de perigo

Acute Tox. 3 Oral - STOT SE 3

Órgãos-alvo

Central nervous system

Código de classe de armazenamento

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

Classe de risco de água (WGK)

WGK 3

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable

Certificados de análise (COA)

Busque Certificados de análise (COA) digitando o Número do Lote do produto. Os números de lote e remessa podem ser encontrados no rótulo de um produto após a palavra “Lot” ou “Batch”.

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Michael J Krashes et al.
The Journal of clinical investigation, 121(4), 1424-1428 (2011-03-03)
Several different neuronal populations are involved in regulating energy homeostasis. Among these, agouti-related protein (AgRP) neurons are thought to promote feeding and weight gain; however, the evidence supporting this view is incomplete. Using designer receptors exclusively activated by designer drugs
Blaine N Armbruster et al.
Proceedings of the National Academy of Sciences of the United States of America, 104(12), 5163-5168 (2007-03-16)
We evolved muscarinic receptors in yeast to generate a family of G protein-coupled receptors (GPCRs) that are activated solely by a pharmacologically inert drug-like and bioavailable compound (clozapine-N-oxide). Subsequent screening in human cell lines facilitated the creation of a family
Daniel J Urban et al.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 41(5), 1404-1415 (2015-09-19)
Elucidating how the brain's serotonergic network mediates diverse behavioral actions over both relatively short (minutes-hours) and long period of time (days-weeks) remains a major challenge for neuroscience. Our relative ignorance is largely due to the lack of technologies with robustness
Susan M Ferguson et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 33(28), 11668-11676 (2013-07-12)
The dorsal striatum has been implicated in reward-based decision making, but the role played by specific striatal circuits in these processes is essentially unknown. Using cell phenotype-specific viral vectors to express engineered G-protein-coupled DREADD (designer receptors exclusively activated by designer
Susan M Ferguson et al.
Nature neuroscience, 14(1), 22-24 (2010-12-07)
Dorsal striatum is important for the development of drug addiction; however, a precise understanding of the roles of striatopallidal (indirect) and striatonigral (direct) pathway neurons in regulating behaviors remains elusive. Using viral-mediated expression of an engineered G protein-coupled receptor (hM(4)D)
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