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SML2141

Sigma-Aldrich

Solifenacin succinate

≥98% (HPLC)

Sinônimo(s):

(1S)-(3R)-1-azabicyclo[2.2.2]oct-3-yl 3,4­dihydro-1-phenyl-2(1H)-iso-quinolinecarboxylate succinate, YM905

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About This Item

Fórmula empírica (Notação de Hill):
C23H26N2O2 · C4H6O4
Número CAS:
242478-38-2
Peso molecular:
480.55
Número MDL:
MFCD00954234
Código UNSPSC:
12352200
NACRES:
NA.77

Nível de qualidade

100

Ensaio

≥98% (HPLC)

forma

powder

atividade óptica

[α]/D +35 to +45°, c = 1 in H2O

condição de armazenamento

desiccated

cor

white to beige

solubilidade

H2O: 2 mg/mL, clear

temperatura de armazenamento

2-8°C

cadeia de caracteres SMILES

OC(CCC(O)=O)=O.O=C(O[C@H]1CN2CCC1CC2)N3[C@@H](C4=CC=CC=C4)C5=CC=CC=C5CC3

InChI

1S/C23H26N2O2.C4H6O4/c26-23(27-21-16-24-13-10-18(21)11-14-24)25-15-12-17-6-4-5-9-20(17)22(25)19-7-2-1-3-8-19;5-3(6)1-2-4(7)8/h1-9,18,21-22H,10-16H2;1-2H2,(H,5,6)(H,7,8)/t21?,22-;/m0./s1

chave InChI

RXZMMZZRUPYENV-DZSUWJOWSA-N

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Ações bioquímicas/fisiológicas

Solifenacin succinate (SOL) blocks the cholinergic signals to M3 receptors by inhibiting the muscarinic M3 receptors in the bladder. This action prevents the contractions of the detrusor muscles in the urinary bladder wall, leading to relaxing the bladder as well as decreasing urinary urgency and nocturia. Thus, SOL is a widely used antimuscarinic agent for treating the contraction of the overactive bladder.

Pictogramas

Health hazard
GHS08

Palavra indicadora

Warning

Frases de perigo

H361d

Classificações de perigo

Repr. 2

Código de classe de armazenamento

11 - Combustible Solids

Classe de risco de água (WGK)

WGK 3

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable

Certificados de análise (COA)

Busque Certificados de análise (COA) digitando o Número do Lote do produto. Os números de lote e remessa podem ser encontrados no rótulo de um produto após a palavra “Lot” ou “Batch”.

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Donald Newgreen et al.
The Journal of urology, 198(4), 928-936 (2017-05-17)
We evaluated the long-term safety and efficacy of once daily oral solifenacin suspension in children (5 to less than 12 years old) and adolescents (12 to less than 18 years old) with overactive bladder. We conducted a 40-week, open label extension
Molecular docking of different ionophores host-guest inclusion complexes for electrochemical determination of solifenacin succinate in pure and pharmaceutical dosage form: Computer aided design
Eissa MS, et al.
Microchemical Journal, Devoted to the Application of Microtechniques in All Branches of Science, 159, 105363-105363 (2020)
Tomomi Oki et al.
British journal of pharmacology, 145(2), 219-227 (2005-03-09)
1 A novel muscarinic receptor antagonist, solifenacin succinate, inhibited specific binding of [N-methyl-(3)H]-scopolamine ([(3)H]-NMS) in the mouse bladder, submaxillary gland and heart in a concentration-dependent manner. This inhibitory effect was greatest in the submaxillary gland, followed by the bladder and
Yoshihiko Ito et al.
Biological & pharmaceutical bulletin, 39(7), 1167-1171 (2016-07-05)
Solifenacin is an antimuscarinic agent used to treat symptoms of overactive bladder. Pharmacologically significant amounts of solifenacin were excreted in the urine of humans taking a clinical dose of this drug. The aim of this study is to measure muscarinic
Stability-indicating HPTLC method for the simultaneous detection and quantification of alfuzosin hydrochloride, solifenacin succinate along with four of their official impurities
Tantawy MA, et al.
Microchemical Journal, Devoted to the Application of Microtechniques in All Branches of Science, 157, 104905-104905 (2020)

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