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Key Documents

SML1118

Sigma-Aldrich

Hepcidin-25 (human) trifluoroacetate salt

≥95% (HPLC)

Sinônimo(s):

DTHFPICIFCCGCCHRSKCGMCCKT trifluoroacetate salt, H-Asp-Thr-His-Phe-Pro-Ile-Cys-Ile-Phe-Cys-Cys-Gly-Cys-Cys-His-Arg-Ser-Lys-Cys-Gly-Met-Cys-Cys-Lys-Thr-OH trifluoroacetate salt, Hepc25 (human), LEAP-1 (Liver-Expressed Antimicrobial Peptide) (human) trifluoroacetate salt, PLTR (Putative Liver Tumor Regressor ) (human)

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About This Item

Fórmula empírica (Notação de Hill):
C113H170N34O31S9 · xC2HF3O2
Número CAS:
342809-17-0
Peso molecular:
2789.35 (free base basis)
Código UNSPSC:
12352200
NACRES:
NA.77

Ensaio

≥95% (HPLC)

forma

powder

cor

white to off-white

Condições de expedição

wet ice

temperatura de armazenamento

−20°C

Amino Acid Sequence

H-Asp-Thr-His-Phe-Pro-Ile-Cys-Ile-Phe-Cys-Cys-Gly-Cys-Cys-His-Arg-Ser-Lys-Cys-Gly-Met-Cys-Cys-Lys-Thr-OH trifluoroacetate salt

Ações bioquímicas/fisiológicas

Hepcidin is the master regulator of iron homeostasis. Hepcidin is found in liver, but also widely distributed in brain, where it may play a role in preventing iron-related neurodegeneration. Hepcidin has anti-inflammatory and antimicrobial activity.
Hepcidin-25 is the major isoform of hepcidin. hepcidin‐25 with reticulocyte hemoglobin content (CHr) in the hepcidin‐25 plot helps to differentiate DA can be differentiated iron‐deficient anemia (IDA) from the anemia of chronic disease (ACD) and the combined state of ACD/IDA. Mutation in the hepcidin gene is associated with the development of severe juvenile hemochromatosis.

Código de classe de armazenamento

11 - Combustible Solids

Classe de risco de água (WGK)

WGK 3

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable

Certificados de análise (COA)

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Association of prohepcidin and hepcidin-25 with erythropoietin response and ferritin in hemodialysis patients.
Kato A, et al.
American Journal of Nephrology, 28(1), 115-121 (2008)
Kyung-Cho Cho et al.
Journal of analytical methods in chemistry, 2018, 9653747-9653747 (2018-07-18)
As advanced mass spectrometry- (MS-) based hepcidin analysis offers to overcome the limitations in analytical methods using antihepcidin, further improvement of MS detection sensitivity for the peptide may enhance the diagnostic value of the hepcidin for various iron-related disorders. Here
Serum hepcidin?25 may replace the ferritin index in the Thomas plot in assessing iron status in anemic patients.
Thomas C, et al.
International Journal of Laboratory Hematology, 33(2), 187-193 (2011)
Mutant antimicrobial peptide hepcidin is associated with severe juvenile hemochromatosis.
Roetto A, et al.
Nature Genetics, 33(1), 21-21 (2003)

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