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SML0531

Sigma-Aldrich

BIO-Acetoxime

≥98% (HPLC)

Sinônimo(s):

(2′Z,3′E)-6-Bromoindirubin-3′-acetoxime, (3Z)-3-[(3E)-3-[(Acetyloxy)imino]-1,3-dihydro-2H-indol-2-ylidene]-6-bromo-1,3-dihydro-2H-Indol-2-one, 6-Bromoindirubin acetoxime, 6-Bromoindirubin-3′-acetoxime, BIA

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About This Item

Fórmula empírica (Notação de Hill):
C18H12BrN3O3
Número CAS:
667463-85-6
Peso molecular:
398.21
Número MDL:
MFCD09037533
Código UNSPSC:
12352200
ID de substância PubChem:
329825535
NACRES:
NA.77

Nível de qualidade

100

Ensaio

≥98% (HPLC)

forma

powder

cor

, dark red to purple

solubilidade

H2O: 2 mg/mL (clear solution, warmed)

temperatura de armazenamento

2-8°C

cadeia de caracteres SMILES

CC(=O)O\N=C1\C(Nc2ccccc12)=C3\C(=O)Nc4cc(Br)ccc34

InChI

1S/C18H12BrN3O3/c1-9(23)25-22-16-12-4-2-3-5-13(12)20-17(16)15-11-7-6-10(19)8-14(11)21-18(15)24/h2-8,20H,1H3,(H,21,24)/b17-15-,22-16+

chave InChI

MENDIXKFTXYTHJ-HPBPSMLHSA-N

Ações bioquímicas/fisiológicas

BIO-Acetoxime is a potent and selective GSK-3a/b inhibitor that reduces invasiveness of gliomas and extends animal survival in intracranial glioma models. Also, BIO-Acetoxime induces Wnt signaling and inhibits CD8+ T cell effector differentiation.

Características e benefícios

This compound is featured on the GSK-3 page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Pictogramas

Exclamation markEnvironment
GHS07,GHS09

Palavra indicadora

Warning

Frases de perigo

H302,H410

Classificações de perigo

Acute Tox. 4 Oral - Aquatic Acute 1 - Aquatic Chronic 1

Código de classe de armazenamento

11 - Combustible Solids

Classe de risco de água (WGK)

WGK 3

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable

Certificados de análise (COA)

Busque Certificados de análise (COA) digitando o Número do Lote do produto. Os números de lote e remessa podem ser encontrados no rótulo de um produto após a palavra “Lot” ou “Batch”.

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Ken Ohara et al.
Nephrology (Carlton, Vic.), 24(9), 904-911 (2018-12-24)
Sodium-glucose cotransporter 2 (SGLT2) inhibitors are an antihyperglycemic drug with diuretic properties. We recently reported that an SGLT2 inhibitor ameliorated extracellular fluid expansion with a transient increase in urinary Na+ excretion. However, the effects of SGLT2 inhibitors on fluid distribution
Alessandra Tramontano et al.
Archives of gerontology and geriatrics, 68, 49-54 (2016-09-21)
To assess the prevalence of sarcopenia and associated factors in a population of older people living in a rural area of the Peruvian Andes. The study concerned 222 people aged ≥65 years. Sarcopenia was diagnosed on the basis of skeletal
Amelia Brunani et al.
Respiration; international review of thoracic diseases, 94(6), 493-500 (2017-10-05)
Obese men show higher O2 consumption than lean men during physical exercise, with a trend toward higher peripheral O2 extraction; this is probably due to their larger muscle mass. The aim of this study was to examine this phenomenon by
Qiushi Li et al.
Nature communications, 11(1), 1190-1190 (2020-03-07)
Genes in plant secondary metabolic pathways enable biosynthesis of a range of medically and industrially important compounds, and are often clustered on chromosomes. Here, we study genomic clustering in the benzylisoquinoline alkaloid (BIA) pathway in opium poppy (Papaver somniferum), exploring
J Casper Swarte et al.
Journal of clinical medicine, 9(2) (2020-02-07)
Renal transplantation is life-changing in many aspects. This includes changes to the gut microbiome likely due to exposure to immunosuppressive drugs and antibiotics. As a consequence, renal transplant recipients (RTRs) might suffer from intestinal dysbiosis. We aimed to investigate the
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