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SML0207

Sigma-Aldrich

SB 328437

≥98% (HPLC)

Sinônimo(s):

L-Phenylalanine, N-(1-naphthalenylcarbonyl)-4-nitro-, methyl ester

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About This Item

Fórmula empírica (Notação de Hill):
C21H18N2O5
Número CAS:
247580-43-4
Peso molecular:
378.38
Número MDL:
MFCD16618397
Código UNSPSC:
12352202
ID de substância PubChem:
329825229
NACRES:
NA.77

Ensaio

≥98% (HPLC)

Formulário

powder

cor

white to tan

solubilidade

DMSO: ≥10 mg/mL

originador

GlaxoSmithKline

temperatura de armazenamento

2-8°C

cadeia de caracteres SMILES

COC(=O)[C@H](Cc1ccc(cc1)[N+]([O-])=O)NC(=O)c2cccc3ccccc23

InChI

1S/C21H18N2O5/c1-28-21(25)19(13-14-9-11-16(12-10-14)23(26)27)22-20(24)18-8-4-6-15-5-2-3-7-17(15)18/h2-12,19H,13H2,1H3,(H,22,24)/t19-/m0/s1

chave InChI

VMFGCGRAIBLAFY-IBGZPJMESA-N

Aplicação

SB 328437 may be used to study CCR3-mediated cell signaling in asthma models.

Ações bioquímicas/fisiológicas

SB 328437 inhibits the recruitment and migration of eosinophils in allergen models of models. It suppresses the Th2-mediated eosinophil infiltration in the airways.
SB-328437 is a CCR3 Antagonist.
SB-328437 is a potent, selective CCR-3 antagonist (IC50 = 1.6 nM). The compound blockes CCR3 agonist-induced calcium mobilization in CCR3 expressing cells with the following IC50 values: eotaxin, 38 nM; eotaxin-2, 35 nM and MCP4, 20 nM.

Características e benefícios

This compound is featured on the Chemokine Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
This compound was developed by GlaxoSmithKline. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Código de classe de armazenamento

11 - Combustible Solids

Classe de risco de água (WGK)

WGK 3

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable

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Certificados de análise (COA)

Lot/Batch Number
101M4632V

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International immunology, 19(8), 913-921 (2007-09-07)
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