SML0113

Brequinar sodium salt hydrate

≥97% (HPLC)

• Sinônimo(s): 6-Fluoro-2-(2′-fluoro[1,1′-biphenyl]-4-yl)-3-methyl-4-quinolinecarboxylic acid sodium hydrate, Biphenquinate sodium hydrate, DuP 785 hydrate, NSC 368390 hydrate
• Fórmula empírica (Notação de Hill): C₂₃H₁₄F₂NO₂·Na · xH₂O
• Número CAS: 96187-53-0
• Peso molecular: 397.35 (anhydrous basis)
• Número MDL: MFCD21363375
• Código UNSPSC: 12352200
• ID de substância PubChem: 329825165
• NACRES: NA.77

Propriedades

• Ensaio: ≥97% (HPLC)
• forma: powder
• cor: off-white to brown
• solubilidade: DMSO: ≥5 mg/mL
• temperatura de armazenamento: 2-8°C
• cadeia de caracteres SMILES: O.[Na+].Cc1c(nc2ccc(F)cc2c1C([O-])=O)-c3ccc(cc3)-c4ccccc4F
• InChI: 1S/C23H15F2NO2.Na.H2O/c1-13-21(23(27)28)18-12-16(24)10-11-20(18)26-22(13)15-8-6-14(7-9-15)17-4-2-3-5-19(17)25;;/h2-12H,1H3,(H,27,28);;1H2/q;+1;/p-1
• chave InChI: IZXTTXFXRQGHKO-UHFFFAOYSA-M

Descrição

Aplicação

Brequinar sodium salt hydrate has been used as a dihydroorotate dehydrogenase (DHODH) inhibitor:

• in drug response assays
• to induce depletion of cellular pyrimidine pools
• in cell proliferation assays

Brequinar sodium salt hydrate may be used in cell signaling studies.

Ações bioquímicas/fisiológicas

Brequinar exhibits anti-neoplastic activity against refractory solid tumors in human and mouse models. Continuous treatment is required for depletion of pyrimidine pools in the cancer cells and tumor inhibition.

Brequinar inhibits dihydroorotate dehydrogenase (DHODH), the fourth enzyme in the de novo pyrimidine biosynthesis pathway, preventing the synthesis of DNA and RNA. Brequinar has recently been found to have antiviral activity against a broad spectrum of viruses including flaviviruses (dengue virus, West Nile virus, yellow fever virus, and Powassan virus) and also a plus-strand RNA alphavirus (Western equine encephalitis virus) and a negative-strand RNA rhabdovirus (vesicular stomatitis virus).

Informações de segurança

• Código de classe de armazenamento: 11 - Combustible Solids
• Classe de risco de água (WGK): WGK 3
• Ponto de fulgor (°F): Not applicable
• Ponto de fulgor (°C): Not applicable