SCP0170
Granulocyte Elastase Substrate human
≥95% (HPLC), lyophilized
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About This Item
Fórmula empírica (Notação de Hill):
C21H27N5O6
Peso molecular:
445.47
Código UNSPSC:
12352204
NACRES:
NA.32
Produtos recomendados
product name
Granulocyte Elastase Substrate human,
Ensaio
≥95% (HPLC)
forma
lyophilized
composição
Peptide Content, ≥85%
condição de armazenamento
protect from light
temperatura de armazenamento
−20°C
Amino Acid Sequence
Glp-Pro-Val-pNA
Descrição geral
Elastase, a glycoprotein, is a member of the serine proteases family. It is synthesized by human polymorphonuclear (PMN) leukocytes or by the pancreas. Human granulocyte elastase is liberated in large amounts from granulocytes in chronic inflammatory joint disorders.
Ações bioquímicas/fisiológicas
Elastase is a catalytic enzyme that catalyzes the cleavage of carboxyl groups on tiny hydrophobic amino acids including glycine, alanine, and valine. Its main function is to break down elastin. Free elastase in some purulent synovial fluids plays a key role in articular cartilage breakdown. Increased elastase levels in the plasma have been seen in patients with evident rheumatoid arthritis.
Elastase(s) can be assayed and differentiated using chromogenic and fluorogenic Pro-Val peptide substrates such as Glp-Pro-Val-pNA and MeOSuc-Ala-Ala-Pro-Val-4-MNA.
Código de classe de armazenamento
11 - Combustible Solids
Classe de risco de água (WGK)
WGK 3
Ponto de fulgor (°F)
Not applicable
Ponto de fulgor (°C)
Not applicable
Certificados de análise (COA)
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Effects of Nigella (Nigella sativa L.) Seed Extract on Human Neutrophil Elastase Activity
Kacem R
Nuts and Seeds in Health and Disease Prevention, 823-829 (2011)
K Kleesiek et al.
Rheumatology international, 6(4), 161-169 (1986-01-01)
Human granulocyte elastase (EC 3.4.21.37) is released from granulocytes in large amounts in chronic inflammatory joint diseases and is therefore of special pathogenic and diagnostic importance. In order to examine the diagnostic significance of this enzyme as a clinico-chemical parameter
Use of Extracts from Squirting Cucumber (Ecballium elaterium) Seeds in Health
Attard E
Nuts and Seeds in Health and Disease Prevention, 1079-1086 (2011)
J V Edwards et al.
The journal of peptide research : official journal of the American Peptide Society, 66(4), 160-168 (2005-09-06)
An assessment of elastase-substrate kinetics and adsorption at the solid-liquid interface of peptide-bound resin was made in an approach to the solid-phase detection of human neutrophil elastase (HNE), which is found in high concentration in chronic wound fluid. N-succinyl-alanine-alanine-proline-valine-p-nitroanilide (suc-Ala-Ala-Pro-Val-pNA)
G Dent et al.
Lung, 173(3), 165-175 (1995-01-01)
Elastase and antielastase activities were measured in bronchoalveolar lavage fluid (BALF) and their relationship to bronchoalveolar lavage (BAL) neutrophil numbers was assessed in order to determine whether the elevated BAL neutrophil count can predict a shift in the elastase/antielastase balance.
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