SAB4700097
Monoclonal Anti-CD14 antibody produced in mouse
clone MEM-15, purified immunoglobulin, buffered aqueous solution
Sinônimo(s):
Anti-LPS-receptor
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About This Item
Código UNSPSC:
12352203
NACRES:
NA.43
Produtos recomendados
fonte biológica
mouse
Nível de qualidade
conjugado
unconjugated
forma do anticorpo
purified immunoglobulin
tipo de produto de anticorpo
primary antibodies
clone
MEM-15, monoclonal
forma
buffered aqueous solution
reatividade de espécies
human, nonhuman primates
concentração
1 mg/mL
técnica(s)
flow cytometry: suitable
Isotipo
IgG1
nº de adesão NCBI
nº de adesão UniProt
Condições de expedição
wet ice
temperatura de armazenamento
2-8°C
modificação pós-traducional do alvo
unmodified
Informações sobre genes
human ... CD14(929)
Descrição geral
CD14 (cluster of differentiation 14) is a myelomonocytic differentiation antigen, encoded by the gene mapped to human chromosome 5q23-31. It is mainly expressed by monocytes, macrophages and activated granulocytes.
Imunogênio
A crude mixture of human urinary proteins precipitated by ammonium sulphate from the urine of a patient suffering from proteinuria
Aplicação
The reagent is designed for Flow Cytometry analysis. Suggested working dilution for Flow Cytometry is 4 μg/mL of sample. Indicated dilution is recommended starting point for use of this product. Working concentrations should be determined by the investigator.
Ações bioquímicas/fisiológicas
CD14 (cluster of differentiation 14) serves as an important receptor of bacterial lipopolysaccharide (LPS). CD14 and LPs complex interacts with toll-like receptor 4 and enhances the expression of inflammatory mediators, including tumor necrosis factor (TNF)- and interleukin (IL)-1, via p38 mitogen-activated protein kinase and nuclear factor-B pathway. Mutation in the gene is associated with the development of myeloid leukemias and generalized chronic periodontitis (GCP).
Características e benefícios
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
forma física
Solution in phosphate buffered saline, pH 7.4, with 15 mM sodium azide.
Exoneração de responsabilidade
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Código de classe de armazenamento
10 - Combustible liquids
Ponto de fulgor (°F)
Not applicable
Ponto de fulgor (°C)
Not applicable
Certificados de análise (COA)
Busque Certificados de análise (COA) digitando o Número do Lote do produto. Os números de lote e remessa podem ser encontrados no rótulo de um produto após a palavra “Lot” ou “Batch”.
Já possui este produto?
Encontre a documentação dos produtos que você adquiriu recentemente na biblioteca de documentos.
Synergistic contribution of CD14 and HLA loci
in the susceptibility to Buerger disease
Chen Z
Human Genetics, 122, 367-372 (2007)
The CD14 monocyte differentiation antigen maps to a region encoding growth factors and receptors.
Goyert SM
Science, 239, 497-500 (1988)
Cytogenetic and molecular delineation of the smallest commonly
deleted region of chromosome 5 in malignant myeloid diseases
Le Beau MM
Proceedings of the National Academy of Sciences of the USA, 90, 5484-5488 (1993)
Dilshi Ishaan et al.
Genetic testing and molecular biomarkers, 21(9), 560-564 (2017-08-23)
The genetic variation in the CD14 rs2569190 promoter region contributes to the susceptibility of developing periodontitis. Since, CD14 gene polymorphism studies among various ethnic populations have produced conflicting results, the present study was designed to unearth the association between the
D P Funda et al.
Infection and immunity, 69(6), 3772-3781 (2001-05-12)
Human endothelial as well as epithelial cells were shown to respond to lipopolysaccharides (LPSs). However, the expression and release of CD14 by these so-called CD14-negative cells have not been studied in detail. We investigated three human intestinal epithelial cell lines
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