SAB4501342

Anti-CARD10 antibody produced in rabbit

affinity isolated antibody

• Sinônimo(s): CARD-containing MAGUK protein 3, CARD10, CARMA3, Carma 3, Caspase recruitment domain-containing protein 10
• Código UNSPSC: 12352203
• NACRES: NA.41
• conjugado: unconjugated
• application: ELISA; IF; WB
• clone: polyclonal
• reatividade de espécies: mouse, human
• citations: 2
• técnica(s): ELISA: 1:1000; immunofluorescence: 1:100-1:500; western blot: 1:500-1:1000

Propriedades

• fonte biológica: rabbit
• Nível de qualidade: 100
• conjugado: unconjugated
• forma do anticorpo: affinity isolated antibody
• tipo de produto de anticorpo: primary antibodies
• clone: polyclonal
• Formulário: buffered aqueous solution
• peso molecular: antigen 115 kDa
• reatividade de espécies: mouse, human
• concentração: ~1 mg/mL
• técnica(s): ELISA: 1:1000; immunofluorescence: 1:100-1:500; western blot: 1:500-1:1000
• nº de adesão NCBI: Q9BWT7
• nº de adesão UniProt: Q9BWT7
• Condições de expedição: wet ice
• temperatura de armazenamento: −20°C
• modificação pós-traducional do alvo: unmodified
• Informações sobre genes: human ... CARD10(29775)

Descrição

Descrição geral

Anti-CARD10 antibody detects endogenous levels of total CARD10 protein.

CARD10 (caspase recruitment domain-containing protein 10) is an important BCL10 (B-cell CLL/lymphoma 10) interactor. It is a member of membrane-associated guanylate kinase family. It is mapped to human chromosome 22q13.1. The CARD10 protein has 1032 amino acids with an estimated molecular weight of 116 kDa. It consists of five putative functional domains, an N-terminal CARD domain, a central coiled-coil domain, and a C-terminal tripartite structure consisting of a PDZ (post synaptic density protein (PSD95), drosophila disc large tumor suppressor (Dlg1) and zonula occludens-1 protein) domain, an SH3 (SRC homology 3 domain) domain, and a GUK (guanylate kinases) domain with homology to guanylate kinase. In several adult tissues, including heart, kidney, and liver, it is expressed as a 4.4-kilobase transcript.

Imunogênio

The antiserum was produced against synthesized peptide derived from human CARD10.

Immunogen Range: 481-530

Ações bioquímicas/fisiológicas

CARD10 (Caspase recruitment domain-containing protein 10) helps to arrange signaling complexes at plasma membrane. It also serves as a molecular scaffold for the assembly of a B-cell CLL/lymphoma 10 (BCL10) signaling complex that activates NF-κB (nuclear factor-κB).

Características e benefícios

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forma física

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Exoneração de responsabilidade

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Informações de segurança

• Código de classe de armazenamento: 10 - Combustible liquids
• Classe de risco de água (WGK): nwg
• Ponto de fulgor (°F): Not applicable
• Ponto de fulgor (°C): Not applicable