SAB4301170

Anti-pan-AKT antibody produced in rabbit

affinity isolated antibody

• Sinônimo(s): PKB, PKB-ALPHA, PRKBA, RAC, RAC-ALPHA
• Código UNSPSC: 12352203
• NACRES: NA.41
• clone: polyclonal
• application: WB
• reatividade de espécies: rat, human, mouse
• técnica(s): western blot: 1:500-1:1000 (Cell Lysate)
• citations: 7

Propriedades

• fonte biológica: rabbit
• Nível de qualidade: 100
• forma do anticorpo: affinity isolated antibody
• tipo de produto de anticorpo: primary antibodies
• clone: polyclonal
• Formulário: buffered aqueous solution
• peso molecular: 56 kDa
• reatividade de espécies: rat, human, mouse
• concentração: 2 mg/mL
• técnica(s): western blot: 1:500-1:1000 (Cell Lysate)
• Isotipo: IgG
• nº de adesão: NP_001014431.1
• nº de adesão UniProt: P31749
• Condições de expedição: wet ice
• temperatura de armazenamento: −20°C
• modificação pós-traducional do alvo: unmodified
• Informações sobre genes: human ... AKT1(207)

Descrição

Descrição geral

AKT serine/threonine kinase 1 (AKT1) also called as v-akt murine thymoma viral oncogene homolog 1 or protein kinase B α (PKB α) is encoded by the gene mapped to human chromosome 14q32. It is highly expressed in liver, muscle and adipocytes. The encoded protein is a member of AKT family, which is characterized with an amino-terminal pleckstrin homology (PH) domain, a short α-helical linker and a carboxyl-terminal kinase domain.

Especificidade

The antibody detects endogenous levels of total pan-AKT protein.

Imunogênio

Synthetic peptide corresponding to a region derived from internal residues of human RAC-alpha serine/threonine-protein kinase

Aplicação

Anti-pan-AKT antibody produced in rabbit has been used in immunoblotting.

Ações bioquímicas/fisiológicas

AKT serine/threonine kinase 1 (AKT1) acts as a regulator for cell-survival and anti-apoptotic actions which are involved in development of various cancers. This protein has a crucial role in tumorigenesis. In mice, AKT1 is essential for normal development. Mutations in the gene are associated with the pathogenesis of prostate cancer (PC). Elevated expression of the gene has been observed in human gastric cancer. Aberrations in the AKT1 and glycogen synthase kinase 3 (GSK3)-β signaling leads to the development of schizophrenia.

Características e benefícios

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forma física

Rabbit IgG in pH7.3 PBS, 0.05% NaN₃, 50% Glycerol.

Exoneração de responsabilidade

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Informações de segurança

• Código de classe de armazenamento: 10 - Combustible liquids
• Classe de risco de água (WGK): WGK 1
• Ponto de fulgor (°F): Not applicable
• Ponto de fulgor (°C): Not applicable