SAB4301113

Anti-RAS antibody produced in rabbit

affinity isolated antibody

• Sinônimo(s): CTLO, HAMSV, HRAS1, K-RAS, v-Ha-ras Harvey rat sarcoma viral oncogene homolog
• Código UNSPSC: 12352203
• NACRES: NA.41

Propriedades

• fonte biológica: rabbit
• Nível de qualidade: 100
• forma do anticorpo: affinity isolated antibody
• tipo de produto de anticorpo: primary antibodies
• clone: polyclonal
• forma: buffered aqueous solution
• peso molecular: 21 kDa
• reatividade de espécies: mouse, rat, human
• concentração: 0.7 mg/mL
• técnica(s): western blot: 1:200-1:1000 (Cell Lysate)
• Isotipo: IgG
• nº de adesão: NP_001123914.1
• nº de adesão UniProt: P01112
• Condições de expedição: wet ice
• temperatura de armazenamento: −20°C
• modificação pós-traducional do alvo: unmodified
• Informações sobre genes: human ... HRAS(3265)

Descrição

Descrição geral

Ras is a proto-oncogene and the gene encoding it is localized on human chromosome 11p15.5. It is a 21 kDa protein and is part of the small GTP-binding proteins superfamily.

Especificidade

The antibody detects endogenous level of total RAS protein.

Imunogênio

Synthetic peptide corresponding to a region derived from 60-74 amino acids of Human v-Ha-ras Harvey rat sarcoma viral oncogene homolog

Ações bioquímicas/fisiológicas

Ras is a guanine-nucleotide binding protein that couples tyrosine kinase receptor signals to mitogen activated protein (MAP) kinase cascade. It has an important role in cell growth. Ras is a substrate for farnesyltransferase (FTase) and when farnesylated, it is anchored to the membrane. Membrane localization of Ras is crucial for its cellular activity. Inhibition of Ras farnesylation is a target for anti-cancer drug development.

Características e benefícios

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

forma física

Supplied at 0.7mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.3, 0.05% sodium azide and 50% glycerol.

Exoneração de responsabilidade

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Informações de segurança

• Código de classe de armazenamento: 10 - Combustible liquids
• Classe de risco de água (WGK): WGK 1
• Ponto de fulgor (°F): Not applicable
• Ponto de fulgor (°C): Not applicable