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Key Documents

SAB4301078

Sigma-Aldrich

Anti-TDP2 antibody produced in rabbit

affinity isolated antibody

Sinônimo(s):

AD022, EAP2, EAPII, TTRAP, hTDP2

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About This Item

Código UNSPSC:
12352203
NACRES:
NA.41

fonte biológica

rabbit

Nível de qualidade

100

forma do anticorpo

affinity isolated antibody

tipo de produto de anticorpo

primary antibodies

clone

polyclonal

forma

buffered aqueous solution

peso molecular

41 kDa

reatividade de espécies

human, mouse

concentração

2.6 mg/mL

técnica(s)

immunohistochemistry: 1:50- 1:200
western blot: 1:200-1:1000 (Cell Lysate)

Isotipo

IgG

nº de adesão

NP_057698.2

nº de adesão UniProt

O95551

Condições de expedição

wet ice

temperatura de armazenamento

−20°C

modificação pós-traducional do alvo

unmodified

Informações sobre genes

human ... TDP2(51567)

Descrição geral

Tyrosyl DNA phosphodiesterase-2 (TDP2) is a multi-functional protein and is also called as TTRAP (TNF receptor-associated protein). It is a 5′- tyrosyl DNA phosphodiesterase that belongs to the PML NB (promyelocytic leukemia nuclear body) protein family. TDP2 is mapped to human chromosome 6p22.

Especificidade

The antibody detects endogenous levels of total TDP2 protein.

Imunogênio

Synthetic peptide corresponding to a region derived from internal residues of human tyrosyl-DNA phosphodiesterase 2

Ações bioquímicas/fisiológicas

Chromosomal translocations stimulated by DNA topoisomerase II at the time of gene transcription is repressed by tyrosyl DNA phosphodiesterase-2 (TDP2). It is essential to preserve the chromosome stability in human cells. TDP2 participates in cell proliferation, apoptosis and the repair of DNA damage. It promotes cell cycle arrest and apoptosis in osteosarcoma cells.

Características e benefícios

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

forma física

Rabbit IgG in pH7.3 PBS, 0.05% NaN3, 50% Glycerol.

Exoneração de responsabilidade

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Código de classe de armazenamento

10 - Combustible liquids

Classe de risco de água (WGK)

WGK 1

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable

Certificados de análise (COA)

Busque Certificados de análise (COA) digitando o Número do Lote do produto. Os números de lote e remessa podem ser encontrados no rótulo de um produto após a palavra “Lot” ou “Batch”.

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Tyrosyl-DNA-phosphodiesterases (tdp1 and tdp2).
Pommier Y, et al.
DNA Repair, 19, 114-129 (2014)
Ryuta Watanabe et al.
Molecular biology of the cell, 31(6), 478-490 (2020-01-23)
SPOP, speckle-type POZ protein is a substrate adaptor protein of the Cullin-3/RING ubiquitin E3 complex. The spop gene is the most commonly point mutated in human primary prostate cancers, but the pathological contribution of the SPOP mutations remains unclear. In
Overexpression of TTRAP inhibits cell growth and induces apoptosis in osteosarcoma cells.
Zhou C, et al.
Bmb Reports, 46(2), 113-113 (2013)
TDP2 suppresses chromosomal translocations induced by DNA topoisomerase II during gene transcription.
Gomez-Herreros F, et al.
Nature Communications, 8(1), 233-233 (2017)
Ka Cheong Lee et al.
International journal of molecular sciences, 19(7) (2018-07-18)
DNA topoisomerase II (TOP2) activity involves a normally transient double-strand break intermediate in which the enzyme is coupled to DNA via a 5'-phosphotyrosyl bond. However, etoposide and other topoisomerase drugs poison the enzyme by stabilising this enzyme-bridged break, resulting in
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