SAB4300691
Anti-CD44 antibody produced in rabbit
affinity isolated antibody
Sinônimo(s):
Anti-LHR, Anti-MDU2, Anti-MDU3, Anti-MIC4
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About This Item
Código UNSPSC:
12352203
NACRES:
NA.41
Produtos recomendados
fonte biológica
rabbit
Nível de qualidade
conjugado
unconjugated
forma do anticorpo
affinity isolated antibody
tipo de produto de anticorpo
primary antibodies
clone
polyclonal
Formulário
buffered aqueous solution
peso molecular
~80 kDa
reatividade de espécies
human
concentração
1 mg/mL
técnica(s)
western blot: 1:500-1:1000
Isotipo
IgG
sequência de imunogênio
(Q-N-V-D-M)
nº de adesão NCBI
nº de adesão UniProt
Condições de expedição
wet ice
temperatura de armazenamento
−20°C
modificação pós-traducional do alvo
unmodified
Informações sobre genes
human ... CD44(960)
Descrição geral
The CD44 (cell-surface glycoprotein) gene encodes a transmembrane glycoprotein, and has 20 exon. It is mapped to human chromosome 11p13.
The antibody detects endogenous level of total CD44 protein.
The antibody detects endogenous level of total CD44 protein.
Imunogênio
Peptide sequence around aa. 734-738 (Q-N-V-D-M), according to the protein NP_000601.3
Ações bioquímicas/fisiológicas
Overexpression of CD44 (cell-surface glycoprotein) leads to esophageal squamous cell carcinoma (ESCC). It is involved in cell-cell and cell-extracellular matrix interactions. It plays an important role in lymphocyte homing and lymphocyte activation. It also acts as a metastasis suppressor gene for prostatic cancer.
Características e benefícios
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
Descrição-alvo
Receptor for hyaluronic acid (HA). Mediates cell-cell and cell-matrix interactions through its affinity for HA, and possibly also through its affinity for other ligands such as osteopontin, collagens, and matrix metalloproteinases (MMPs). Adhesion with HA plays an important role in cell migration, tumor growth and progression. Also involved in lymphocyte activation, recirculation and homing, and in hematopoiesis. Altered expression or dysfunction causes numerous pathogenic phenotypes. Great protein heterogeneity due to numerous alternative splicing and post-translational modification events.
forma física
Solution in phosphate-buffered saline containing 0.02% sodium azide and 50% glycerol
Exoneração de responsabilidade
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Código de classe de armazenamento
10 - Combustible liquids
Classe de risco de água (WGK)
WGK 1
Ponto de fulgor (°F)
Not applicable
Ponto de fulgor (°C)
Not applicable
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Encontre a documentação dos produtos que você adquiriu recentemente na biblioteca de documentos.
BGMUT: NCBI dbRBC database of allelic variations of genes encoding antigens of blood group systems
Patnaik SK, et al.
Nucleic Acids Research (2012)
Autophagy supports generation of cells with high CD44 expression via modulation of oxidative stress and Parkin-mediated mitochondrial clearance
Whelan KA, et al.
Oncogene (2017)
Eiji Kobayashi et al.
International journal of molecular sciences, 20(15) (2019-08-03)
Normally ubiquitin C-terminal hydrolase L1 (UCH-L1) is expressed in the central nervous and reproductive systems of adults, but its de novo expression has been detected in many human cancers. There is a growing body of evidence that UCH-L1 de-ubiquitinating (DUB)
Takashi Masui et al.
International journal of oncology, 44(3), 693-699 (2013-12-25)
Head and neck squamous cell carcinoma (HNSCC) is known to have a poor prognosis. The resistance to treatment and distant metastasis are important clinical problems in HNSCC. The epithelial-mesenchymal transition (EMT) is a key process in successful execution of many
Hong-Min Li et al.
Life sciences, 106(1-2), 50-57 (2014-05-02)
Inducible nitric oxide synthase (iNOS) over-expression is considered critical to the death of transplanted cells in infarcted myocardium. The present study was to investigate the effect of iNOS on the survival of transplanted bone marrow mesenchymal stem cells (BMSCs) in
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