SAB4300659
Anti-CD10 antibody produced in rabbit
affinity isolated antibody
Sinônimo(s):
Anti-CALLA, Anti-MGC126681, Anti-MME, Anti-NEP, Anti-SFE
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About This Item
Código UNSPSC:
12352203
NACRES:
NA.41
Produtos recomendados
fonte biológica
rabbit
conjugado
unconjugated
forma do anticorpo
affinity isolated antibody
tipo de produto de anticorpo
primary antibodies
clone
polyclonal
Formulário
buffered aqueous solution
peso molecular
~100 kDa
reatividade de espécies
human, rat, mouse
concentração
1 mg/mL
técnica(s)
western blot: 1:500-1:1000
Isotipo
IgG
sequência de imunogênio
(S-Q-M-D-I)
nº de adesão NCBI
Condições de expedição
wet ice
temperatura de armazenamento
−20°C
modificação pós-traducional do alvo
unmodified
Informações sobre genes
human ... CD10(4311)
Descrição geral
Cluster of differentiation 10 (CD10) is also known as neprilysin (NEP), that is encoded by MME (membrane metallo-endopeptidase) gene. It has 24 exons and is located on chromosome 3q25.1 to q25.2. It is predominantly expressed in kidney. The protein is made of 742 amino acids with molecular weight of nearly 85 to 110kDa.
The antibody detects endogenous level of total CD10 protein.
The antibody detects endogenous level of total CD10 protein.
Imunogênio
Peptide sequence around aa. 6-10 (S-Q-M-D-I), according to the protein NP_000893.2
Ações bioquímicas/fisiológicas
Cluster of differentiation 10 (CD10) plays an important role in the degeneration of neuropeptides. It participates in several renal diseases. It plays a major role in Alzheimer′s disease. It helps in the degradation of β‐amyloid (Aβ) in the central nervous system (CNS).
Características e benefícios
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
Descrição-alvo
Thermolysin-like specificity, but is almost confined on acting on polypeptides of up to 30 amino acids. Biologically important in the destruction of opioid peptides such as Met- and Leu-enkephalins by cleavage of a Gly-Phe bond. Able to cleave angiotensin-1, angiotensin-2 and angiotensin 1-9. Involved in the degradation of atrial natriuretic factor (ANF). Displays UV-inducible elastase activity toward skin preelastic and elastic fibers.
forma física
Solution in phosphate-buffered saline containing 0.02% sodium azide and 50% glycerol
Exoneração de responsabilidade
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Código de classe de armazenamento
10 - Combustible liquids
Classe de risco de água (WGK)
WGK 1
Ponto de fulgor (°F)
Not applicable
Ponto de fulgor (°C)
Not applicable
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Certificados de análise (COA)
Lot/Batch Number
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Encontre a documentação dos produtos que você adquiriu recentemente na biblioteca de documentos.
Mutations in MME cause an autosomal-recessive Charcot-Marie-Tooth disease type 2
Higuchi Y, et al.
Annals of Neurology (2016)
Caroline Plazanet et al.
Pediatric nephrology (Berlin, Germany), 29(7), 1221-1230 (2014-01-31)
Fetuses exposed to angiotensin-converting enzyme inhibitors or angiotensin receptor antagonists during the second and/or third trimesters of gestation are at high risk of developing severe complications. They consist in fetal hypotension, and anuria/oligohydramnios leading to Potter sequence, frequently associated with
Noriko Satake et al.
British journal of haematology, 167(4), 487-499 (2014-09-10)
Conventional chemotherapy for precursor B-cell (preB) acute lymphoblastic leukaemia (ALL) has limitations that could be overcome by targeted therapy. Previously, we discovered a potential therapeutic molecular target, MDX3 (MAX dimerization protein 3), in preB ALL. In this study, we hypothesize
Role of notch signaling in the maintenance of human mesenchymal stem cells under hypoxic conditions.
Hiroyuki Moriyama et al.
Stem cells and development, 23(18), 2211-2224 (2014-06-01)
Human adipose tissue-derived multilineage progenitor cells (hADMPCs) are attractive for cell therapy and tissue engineering because of their multipotency and ease of isolation without serial ethical issues. However, their limited in vitro lifespan in culture systems hinders their therapeutic application.
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