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Key Documents

SAB4300355

Sigma-Aldrich

Anti-PTK2 (Ab-861) antibody produced in rabbit

affinity isolated antibody

Sinônimo(s):

Anti-FADK antibody produced in rabbit, Anti-FAK antibody produced in rabbit, Anti-FAK1 antibody produced in rabbit, Anti-PTK2 protein tyrosine kinase 2 antibody produced in rabbit, Anti-pp125FAK antibody produced in rabbit

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About This Item

Código UNSPSC:
12352203
NACRES:
NA.41

fonte biológica

rabbit

Nível de qualidade

conjugado

unconjugated

forma do anticorpo

affinity isolated antibody

tipo de produto de anticorpo

primary antibodies

clone

polyclonal

forma

buffered aqueous solution

peso molecular

~125 kDa

reatividade de espécies

human

concentração

1 mg/mL

técnica(s)

immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:50-1:100
western blot: 1:500-1:1000

Isotipo

IgG

sequência de imunogênio

(H-I-Y-Q-P)

nº de adesão NCBI

nº de adesão UniProt

Condições de expedição

wet ice

temperatura de armazenamento

−20°C

modificação pós-traducional do alvo

unmodified

Informações sobre genes

human ... PTK2(5747)

Imunogênio

Peptide sequence around aa. 859-863 (H-I-Y-Q-P), according to the protein PTK2.

Características e benefícios

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Descrição-alvo

Non-receptor protein-tyrosine kinase implicated in signaling pathways involved in cell motility, proliferation and apoptosis. Activated by tyrosine-phosphorylation in response to either integrin clustering induced by cell adhesion or antibody cross-linking, or via G-protein coupled receptor (GPCR) occupancy by ligands such as bombesin or lysophosphatidic acid, or via LDL receptor occupancy. Plays a potential role in oncogenic transformations resulting in increased kinase activity.

forma física

Solution in phosphate-buffered saline containing 0.02% sodium azide and 50% glycerol

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Código de classe de armazenamento

10 - Combustible liquids

Classe de risco de água (WGK)

WGK 1

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable


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Jinping Luo et al.
Biochemical and biophysical research communications, 450(3), 1212-1217 (2014-03-29)
Fertilization triggers rapid changes in intracellular free calcium that serve to activate multiple signaling events critical to the initiation of successful development. Among the pathways downstream of the fertilization-induced calcium transient is the calcium-calmodulin dependent protein tyrosine kinase PTK2b or
Nadja Engel et al.
BMC complementary and alternative medicine, 14, 334-334 (2014-09-10)
Jatropha curcas (JCP1), Pyrenacantha staudtii (PS), Picralima nitida (ZI) and Jatropha gossypifolia (JCP2) are plants used in the African folklore for the treatment of various cancers. This study investigated the in vitro anticancer effects of the ethanol extracts against human
Dao Chao Huang et al.
Endocrinology, 155(10), 3739-3749 (2014-07-23)
The role of PTHrP in the highly metastatic human melanoma disease is not known. This study investigates the mechanisms of action of this secreted factor through homozygous inactivation of the Pthrp gene in A375 human melanoma cells. In vitro, Pthrp-ablated
Li Li et al.
Journal of molecular neuroscience : MN, 53(4), 580-589 (2014-01-09)
Glial cell line-derived neurotrophic factor (GDNF) is a potent neurotrophic factor for midbrain dopamine (DA) neurons, while the DA neurons in the ventral tegmental area (VTA) is a crucial part of the neural circuits associated with drug addiction. Recently, more
D Barras et al.
Oncogene, 33(44), 5163-5172 (2013-11-12)
TAT-RasGAP(317-326), a peptide corresponding to the 317-326 sequence of p120 RasGAP coupled with a cell-permeable TAT-derived peptide, sensitizes the death response of various tumor cells to several anticancer treatments. We now report that this peptide is also able to increase

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