SAB4300255

Anti-phospho-NTRK2 (pTyr⁵¹⁵) antibody produced in rabbit

affinity isolated antibody

• Sinônimo(s): Anti-GP145-TrkB antibody produced in rabbit, Anti-TRKB antibody produced in rabbit, Anti-neurotrophic tyrosine kinase, receptor, type 2 antibody produced in rabbit
• Número MDL: MFCD01092509
• Código UNSPSC: 12352203
• NACRES: NA.41

Propriedades

• fonte biológica: rabbit
• conjugado: unconjugated
• forma do anticorpo: affinity isolated antibody
• tipo de produto de anticorpo: primary antibodies
• clone: polyclonal
• Formulário: buffered aqueous solution
• peso molecular: ~140 kDa
• reatividade de espécies: mouse, rat, human
• concentração: 1 mg/mL
• técnica(s): indirect immunofluorescence: 1:100-1:200
• Isotipo: IgG
• sequência de imunogênio: (P-Q-Y-PF-G)
• nº de adesão NCBI: NP_001007098.1
• nº de adesão UniProt: Q16620
• Condições de expedição: wet ice
• temperatura de armazenamento: −20°C
• modificação pós-traducional do alvo: phosphorylation (pTyr515)
• Informações sobre genes: human ... NTRK2(4915)

Descrição

Descrição geral

NTRK2 (neurotrophic tyrosine kinase receptor type 2) is also known as TRKB (tropomyosin receptor kinase B). It belongs to the Trk family of neurotrophin receptors. It is located on chromosome 9q21.32.

Imunogênio

Peptide sequence around phosphorylation site of tyrosine 515 (P-Q-Y(p)-F-G), according to the protein NTRK2.

Aplicação

Anti-phospho-NTRK2 (pTyr515) antibody has been used in western blotting.

Ações bioquímicas/fisiológicas

In NB (neuroblastoma), NTRK2 (neurotrophic tyrosine kinase receptor type 2) controls the favorable and unfavorable clinical actions. It also controls the roles of glutamate receptor and synaptic plasticity in the amygdala .

Características e benefícios

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Descrição-alvo

Receptor for brain-derived neurotrophic factor (BDNF), neurotrophin-3 and neurotrophin-4/5 but not nerve growth factor (NGF). Involved in the development and/or maintenance of the nervous system. This is a tyrosine-protein kinase receptor. Known substrates for the TRK receptors are SHC1, PI-3 kinase, and PLC-gamma-1.

forma física

Solution in phosphate-buffered saline containing 0.02% sodium azide and 50% glycerol

Exoneração de responsabilidade

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Informações de segurança

• Código de classe de armazenamento: 10 - Combustible liquids
• Classe de risco de água (WGK): WGK 1
• Ponto de fulgor (°F): Not applicable
• Ponto de fulgor (°C): Not applicable