SAB4200730

Anti-Connexin 43 antibody, Mouse monoclonal

clone CXN-6, hybridoma cell culture supernatant

• Sinônimo(s): Anti-AVSD3, Anti-CMDR, Anti-CX43, Anti-EKVP, Anti-EKVP3, Anti-GJAL, Anti-HLHS1, Anti-HSS, Anti-ODDD, Anti-PPKCA
• Código UNSPSC: 12352203
• NACRES: NA.41

Propriedades

• fonte biológica: mouse
• Nível de qualidade: 200
• forma do anticorpo: culture supernatant
• tipo de produto de anticorpo: primary antibodies
• clone: CXN-6, monoclonal
• Formulário: buffered aqueous solution
• reatividade de espécies: chicken, rat, feline, bovine, human, porcine, mouse
• embalagem: antibody small pack of 25 μL
• concentração: ~1.0 mg/mL
• técnica(s): immunoblotting: 1:5,000-1:7,500 using mouse myoblast C2C12 cell line extract; immunofluorescence: 1:500-1:1,000 using mouse myoblast C2C12 cell line; immunohistochemistry: 1:200-1:500 using heat-retrieved formalin-fixed, paraffin-embedded mouse heart sections
• Isotipo: IgM
• nº de adesão UniProt: P17302
• Condições de expedição: dry ice
• temperatura de armazenamento: −20°C
• modificação pós-traducional do alvo: unmodified
• Informações sobre genes: bovine ... Gja1(281193) ; cat ... Gja1(101100211) ; chicken ... Gja1(395278) ; human ... GJA1(2697) ; mouse ... Gja1(14609) ; rat ... Gja1(24392)

Descrição

Descrição geral

Connexin 43 (Cx43) is also known as gap junction alpha-1 protein (GJA1). It is mapped to human chromosome 6q22.31. Cx43 is membrane protein with four transmembrane spanning regions, which comprise the gap junction channel. The loop connecting the transmembrane regions play a key role in channel docking. The N- and C-terminal amino acids are exposed to cytoplasm.

Imunogênio

synthetic peptide from the C-terminal region of Connexin 43 protein, conjugated to KLH

Ações bioquímicas/fisiológicas

Connexin 43 (Cx43) function is controlled by phosphorylation, SUMOylation and ubiquitination. The C-terminal tail of Cx43 modulates cytoskeletal dynamics and cell migration properties. Mutation in Cx43 leads to dysfunction of channel regulation domain and is associated with pathogenesis of hypoplastic left heart syndrome (HLHS). Cx43 dysregulation in testis contributes to infertility and testicular tumor. A gene mutation in the Cx43 results in abnormal development of eyes and teeth in oculodentodigital dysplasia (ODDD) , craniometaphyseal dysplasia and sudden infant death syndrome. Mutations in the GJA1 results in abnormal facial and skull development in hallermann-streiff syndrome (HSS). Missense mutations in GJA1 gene is also implicated in skin disorder called the, erythrokeratodermia variabilis et progressiva (EKVP)

forma física

The product is supplied as a culture supernatant solution containing 15 mM sodium azide as a preservative. The product contains bovine serum albumin and a human-derived protein.

Exoneração de responsabilidade

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Informações de segurança

• Código de classe de armazenamento: 10 - Combustible liquids
• Classe de risco de água (WGK): WGK 1
• Ponto de fulgor (°F): Not applicable
• Ponto de fulgor (°C): Not applicable