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SAB4200700

Sigma-Aldrich

Anti-MR-Pro ADM antibody, Mouse monoclonal

clone MR2.1, purified from hybridoma cell culture

Sinônimo(s):

Midregional proadrenomedullin

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About This Item

Código UNSPSC:
51111800
NACRES:
NA.41

fonte biológica

mouse

Nível de qualidade

200

conjugado

unconjugated

forma do anticorpo

purified immunoglobulin

tipo de produto de anticorpo

primary antibodies

clone

MR2.1, monoclonal

Formulário

buffered aqueous solution

reatividade de espécies

human

concentração

~1 mg/mL

técnica(s)

immunoblotting: 1-2 μg/mL using human recombinant peptide of MR-Pro ADM (amino acid 45-92)
immunohistochemistry: 2.5-5 μg/mL using Biotin/ExtrAvidin®-Peroxidase staining system of heat-retrieved formalin-fixed, paraffin-embedded human Pancreas sections

Isotipo

IgG2a

nº de adesão UniProt

P35318

Condições de expedição

dry ice

temperatura de armazenamento

−20°C

modificação pós-traducional do alvo

unmodified

Informações sobre genes

human ... ADM(133)

Descrição geral

Anti-MR-Pro ADM antibody, Mouse monoclonal (MidRegional pro-Adrenomedullin) (mouse IgG2a isotype) is derived from the hybridoma MR2.1 produced by the fusion of mouse myeloma cells and splenocytes from BALB/c mice immunized with a synthetic peptide corresponding to the internal region of human Adrenomedullin (ADM), conjugated to KLH. The precursor peptide of Adrenomedullin (ADM), prepro-ADM, is processed to the circulating form of ADM. During this processing, other peptides are also being generated; PAMP (proadrenomedullin N-terminal 20 peptide) with suggested hypotensive effect, and MR-pro ADM (Mid-Regional pro-Adrenomedullin) which consists of 47 amino acid-propeptide.

Imunogênio

Synthetic peptide corresponding to the internal region of human Adrenomedullin (ADM), conjugated to KLH.

Aplicação

Anti-MR-Pro ADM antibody has been used in immunoblotting, immunohistochemistry.

Ações bioquímicas/fisiológicas

MR-pro ADM (MidRegional pro-Adrenomedullin) has been suggested as a biomarker for plasma concentrations of Adrenomedullin as it is stoichiometrically generated and relatively stable in the plasma. Increased levels of MR-pro ADM were associated with an increased risk of mortality and morbidity in patients with heart failure, independent of natriuretic peptides. In dialysis patients MR-pro ADM and MR-pro ANP were shown to be associated with mortality in general and particularly with cardiovascular related mortality, with the highest risk when both parameters were elevated.

forma física

Solution in 0.01 M phosphate buffered saline pH 7.4, containing 15 mM sodium azide

Informações legais

ExtrAvidin is a registered trademark of Merck KGaA, Darmstadt, Germany

Exoneração de responsabilidade

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Código de classe de armazenamento

10 - Combustible liquids

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable

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Certificados de análise (COA)

Lot/Batch Number
056M4767V

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Mid-regional pro-adrenomedullin as a prognostic marker in sepsis: an observational study
Christ-Crain M, et al.
Critical Care, 9(6), R816-R816 (2005)
Prognostic value of mid-regional pro-adrenomedullin in patients with heart failure after an acute myocardial infarction
Klip I T, et al.
Heart, 97(11), 892-898 (2011)
W Frank Peacock
Clinical chemistry and laboratory medicine, 52(10), 1433-1435 (2014-04-24)
First isolated from human pheochromocytoma cells, adrenomedullin (ADM) is a peptide hormone with natriuretic, vasodilatory, and hypotensive effects mediated by cyclic adenosine monophosphate (cAMP), nitric oxide, and renal prostaglandin systems. ADM expression occurs in many tissues and organ systems, including
Adrenomedullin, a multifunctional regulatory peptide.
Hinson JP, et al.
Endocrine Reviews, 21(2), 138-167 (2000)
Mihael Potocki et al.
Current heart failure reports, 9(3), 244-251 (2012-06-27)
Circulating biomarkers have become increasingly important in diagnosing and risk-stratifying patients with heart failure (HF). While the natriuretic peptides have received much focus in the past decade, there is increasing interest in the role of other circulating biomarkers such as
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