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Documentos Principais

SAB4200575

Sigma-Aldrich

Anti-SLC40A1 antibody produced in rabbit

IgG fraction of antiserum

Sinônimo(s):

Ferroportin-1(FPN1), HFE4, IREG1, MST079, MSTP079, MTP1, SLC11A3, solute carrier family 40 (iron-regulated transporter) member 1,

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About This Item

Código UNSPSC:
12352203
NACRES:
NA.41

fonte biológica

rabbit

Nível de qualidade

200

forma do anticorpo

IgG fraction of antiserum

tipo de produto de anticorpo

primary antibodies

Formulário

buffered aqueous solution

peso molecular

~60 kDa

reatividade de espécies

rat, human

técnica(s)

immunoblotting: 1:1,000-1:2,000 using rat kidney extracts (S1 fraction)
immunohistochemistry: 1:50-1:100 using formalin-fixed paraffin-embedded human duodenum

nº de adesão UniProt

Q9NP59

Condições de expedição

dry ice

temperatura de armazenamento

−20°C

modificação pós-traducional do alvo

unmodified

Informações sobre genes

human ... SLC40A1(30061)
rat ... Slc40a1(170840)

Descrição geral

SLC40A1 (also known as ferroportin, FPN1), also called iron-regulated transporter 1 (IREG1), is an iron transporter expressed in liver, duodenum and kidney. SLC40A1 is also expressed in the brain, duodenal mucosa, in neuronal cells and endothelial cells of the blood-brain barrier.

Imunogênio

synthetic peptide corresponding to an internal sequence of human SLC40A1, conjugated to KLH.

Aplicação

Anti-SLC40A1 antibody produced in rabbit has been used in western blotting and immunohistochemistry.

Ações bioquímicas/fisiológicas

Ferroportin 1(FPN1) plays a central role in systemic iron homeostasis and is critical for normal intestinal iron absorption. SLC40A1 is essential for development of the mouse embryo, forebrain patterning and neural tube closure. Hepcidin binds to and inhibits solute carrier family FPN1, thus preventing enterocytes of the intestines from secreting iron into the hepatic portal system, thereby functionally reducing iron absorption. Ferroportin in neuronal cells is required for cellular Fe2+ export, a process critical for normal neuronal function. It has been shown to interact with amyloid precursor protein (APP), to facilitate the iron export process from neuronal cells. Mutations in the FPN1 gene have been linked to hereditary hemochromatosis, a common disorder characterized by iron overload and multi-organ damage.

forma física

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.

Exoneração de responsabilidade

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Código de classe de armazenamento

10 - Combustible liquids

Classe de risco de água (WGK)

WGK 2

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable

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Certificados de análise (COA)

Lot/Batch Number
033M4798V

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Differential regulation of estrogen in iron metabolism in astrocytes and neurons
Xu M, et al.
Journal of Cellular Physiology, 234(4), 4232-4242 (2019)
The iron exporter ferroportin/Slc40a1 is essential for iron homeostasis
Donovan A, et al.
Cell Metabolism, 1(3), 191-200 (2005)
Jinzhe Mao et al.
Development (Cambridge, England), 137(18), 3079-3088 (2010-08-13)
Neural tube defects (NTDs) are some of the most common birth defects observed in humans. The incidence of NTDs can be reduced by peri-conceptional folic acid supplementation alone and reduced even further by supplementation with folic acid plus a multivitamin.
A T McKie et al.
Molecular cell, 5(2), 299-309 (2000-07-06)
Iron absorption by the duodenal mucosa is initiated by uptake of ferrous Fe(II) iron across the brush border membrane and culminates in transfer of the metal across the basolateral membrane to the portal vein circulation by an unknown mechanism. We
Natascha A Wolff et al.
Journal of cellular and molecular medicine, 15(2), 209-219 (2009-12-18)
Ferroportin 1 (FPN1) is an iron export protein expressed in liver and duodenum, as well as in reticuloendothelial macrophages. Previously, we have shown that divalent metal transporter 1 (DMT1) is expressed in late endosomes and lysosomes of the kidney proximal
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