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SAB4200515

Anti-Arc antibody produced in rabbit

Name: Anti-Arc antibody produced in rabbit
Brand: SIGMA

~1.0 mg/mL, affinity isolated antibody

Sinônimo(s):

Anti-Activity-regulated cytoskeleton-associated protein, Anti-Arc3.1, Anti-Arg3.1

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About This Item

Código UNSPSC:

12352203

NACRES:

NA.41

Produtos recomendados

Slide 1 of 1

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Roche

SITRAN-RO

X-tremeGENE^™ siRNA Transfection Reagent

fonte biológica

rabbit

Nível de qualidade

200

conjugado

unconjugated

forma do anticorpo

affinity isolated antibody

tipo de produto de anticorpo

primary antibodies

clone

polyclonal

forma

buffered aqueous solution

peso molecular

antigen ~55 kDa

reatividade de espécies

rat, mouse, human

validação aprimorada

recombinant expression
Learn more about Antibody Enhanced Validation

concentração

~1.0 mg/mL

técnica(s)

immunohistochemistry: 20 μg/mL using formalin-fixed, paraffin-embedded rat brain
western blot: 1.5-3 μg/mL using U937 cell extracts

nº de adesão UniProt

Q7LC44

Condições de expedição

dry ice

temperatura de armazenamento

−20°C

modificação pós-traducional do alvo

unmodified

Informações sobre genes

human ... ARC(23237)
mouse ... Arc(11838)
rat ... Arc(54323)

Descrição geral

Activity regulated cytoskeleton associated protein (Arc) is encoded by the gene mapped to human chromosome 8q24.3.

Imunogênio

synthetic peptide corresponding to a sequence at the C-terminal region of human Arc, conjugated to KLH. The corresponding sequence is identical in rat and mouse Arc.

Ações bioquímicas/fisiológicas

Activity regulated cytoskeleton associated protein (Arc) plays a vital role in memory formation. It also facilitates activity-dependent plasticity of dendrites. Mutation in the gene has been associated with the development of idiopathic generalized epilepsy (IGE).

forma física

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.

Exoneração de responsabilidade

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Código de classe de armazenamento

10 - Combustible liquids

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable

Certificados de análise (COA)

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Mutation screening of the chromosome 8q24.3-human activity-regulated cytoskeleton-associated gene (ARC) in idiopathic generalized epilepsy.

Haug K

Molecular and Cellular Probes, 14, 255-260 (2000)

Insulin-induced expression of the activity-regulated cytoskeleton-associated gene (ARC) in human neuroblastoma cells requires p21ras, mitogen-activated protein kinase/extracellular regulated kinase and src tyrosine kinases but is protein kinase C-independent

Kremerskothen J

Neuroscience Letters, 321, 153-156 (2002)

Arc, a growth factor and activity-regulated gene, encodes a novel cytoskeleton-associated protein that is enriched in neuronal dendrites.

G L Lyford et al.

Neuron, 14(2), 433-445 (1995-02-01)

Neuronal activity is an essential stimulus for induction of plasticity and normal development of the CNS. We have used differential cloning techniques to identify a novel immediate-early gene (IEG) cDNA that is rapidly induced in neurons by activity in models

Enhancement of memories by systemic administration of insulin-like growth factor II.

Sarah A Stern et al.

Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 39(9), 2179-2190 (2014-03-20)

To treat cognitive disorders in humans, new effective therapies that can be easily delivered systemically are needed. Previous studies showed that a bilateral injection of insulin-like growth factor II (IGF-II) into the dorsal hippocampus of rats or mice enhances fear

Noradrenergic actions in the basolateral complex of the amygdala modulate Arc expression in hippocampal synapses and consolidation of aversive and non-aversive memory.

Jayme R McReynolds et al.

Neurobiology of learning and memory, 115, 49-57 (2014-09-10)

The basolateral complex of the amygdala (BLA) plays a role in the modulation of emotional memory consolidation through its interactions with other brain regions. In rats, memory enhancing infusions of the β-adrenergic receptor agonist clenbuterol into the BLA immediately after

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