SAB3700546
Anti-Rat IgG (Fc specific) antibody produced in rabbit
affinity isolated antibody, buffered aqueous solution
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About This Item
Código UNSPSC:
12352203
NACRES:
NA.46
Produtos recomendados
fonte biológica
rabbit
conjugado
unconjugated
forma do anticorpo
affinity isolated antibody
tipo de produto de anticorpo
secondary antibodies
clone
polyclonal
forma
buffered aqueous solution
reatividade de espécies
rat
concentração
2.0 mg/mL
técnica(s)
immunohistochemistry: suitable
indirect ELISA: suitable
western blot: suitable
Condições de expedição
wet ice
temperatura de armazenamento
2-8°C
modificação pós-traducional do alvo
unmodified
Categorias relacionadas
Descrição geral
IgG contributes to 10−20% of plasma protein and is regarded as one of the most predominant serum protein. It consists of four subclasses: IgG1, IgG2, IgG3 and IgG4. The IgG structure possesses four polypeptide chains containing two identical γ heavy (H) chains and two identical κ or λ light (L) chains of 50kDa and 25kDa respectively. Papain and pepsin digestion yields two main fragments of the antibody: Fab (antigen binding fragment) and Fc (fragment crystallization tail).
Especificidade
This product was prepared from monospecific antiserum by immunoaffinity chromatography using Rat IgG coupled to agarose beads followed by solid phase adsorption(s) to remove any unwanted reactivities. Assay by immunoelectrophoresis resulted in a single precipitin arc against Anti-Rabbit Serum, Rat IgG, Rat IgG F(c) and Rat Serum. No reaction was observed against Rat IgG F(ab′)2.
Imunogênio
Rat IgG F(c) fragment
Ações bioquímicas/fisiológicas
IgG (immunoglobulin G) antibody provides protection against bacterial, fungal and viral infections. Maternal IgG is transferred to fetus through the placenta that is vital for the immune defense of the neonate against infections. The Fc (fragment crystallization tail) region of the antibody is implicated in complement activation in which it elicits an immune response by binding to the Fc receptor on macrophages.
propriedades físicas
Antibody format: IgG
forma física
Supplied in 0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2
Exoneração de responsabilidade
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Código de classe de armazenamento
10 - Combustible liquids
Ponto de fulgor (°F)
Not applicable
Ponto de fulgor (°C)
Not applicable
Certificados de análise (COA)
Busque Certificados de análise (COA) digitando o Número do Lote do produto. Os números de lote e remessa podem ser encontrados no rótulo de um produto após a palavra “Lot” ou “Batch”.
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Role of antibodies in cancer targeting
Attarwala Husain
Journal of natural science, biology, and medicine, 1(1), 53-53 (2010)
Seon Pyo Hong et al.
Nature communications, 11(1), 4102-4102 (2020-08-17)
Emerging evidence suggests that intestinal stromal cells (IntSCs) play essential roles in maintaining intestinal homeostasis. However, the extent of heterogeneity within the villi stromal compartment and how IntSCs regulate the structure and function of specialized intestinal lymphatic capillary called lacteal
Placental transfer of IgG subclasses in a Japanese population.
Hashira S, et al.
Pediatrics International, 42(4) (2000)
Structure and function of immunoglobulins.
Schroeder Jr H W and Cavacini L
The Journal of Allergy and Clinical Immunology, 125(2), S41-S52 (2010)
Gestur Vidarsson et al.
Frontiers in immunology, 5, 520-520 (2014-11-05)
Of the five immunoglobulin isotypes, immunoglobulin G (IgG) is most abundant in human serum. The four subclasses, IgG1, IgG2, IgG3, and IgG4, which are highly conserved, differ in their constant region, particularly in their hinges and upper CH2 domains. These
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