SAB3500356

Anti-MDA5 antibody produced in rabbit

affinity isolated antibody, buffered aqueous solution

• Sinônimo(s): Anti-IFIH1, Anti-Interferon-induced with helicase C domain protein 1, Anti-Melanoma differentiation-associated protein 5
• Código UNSPSC: 12352203
• NACRES: NA.41

Propriedades

• fonte biológica: rabbit
• conjugado: unconjugated
• forma do anticorpo: affinity isolated antibody
• tipo de produto de anticorpo: primary antibodies
• clone: polyclonal
• Formulário: buffered aqueous solution
• peso molecular: predicted mol wt 113 kDa
• reatividade de espécies: mouse, human
• técnica(s): immunofluorescence: suitable; immunohistochemistry: suitable; indirect ELISA: suitable; western blot: suitable
• nº de adesão NCBI: NP_071451
• nº de adesão UniProt: Q9BYX4
• Condições de expedição: dry ice
• temperatura de armazenamento: −20°C
• modificação pós-traducional do alvo: unmodified
• Informações sobre genes: human ... IFIH1(64135)

Descrição

Descrição geral

Melanoma differentiation-associated protein 5 (MDA5), also known as interferon induced with helicase C domain 1 (IFIH1), is a cytosolic RNA sensor. It is encoded by the gene mapped to human chromosome 2q24.2. The encoded protein is a member of the retinoic acid-inducible gene I-like receptor family. MDA5 is characterized with both caspase recruitment domain and putative DExH group RNA helicase domains.

Imunogênio

MDA5 antibody was raised against a 16 amino acid peptide from near the carboxy terminus of human MDA5.

Aplicação

Anti-MDA5 antibody produced in rabbit has been used in western blot analysis.

Ações bioquímicas/fisiológicas

Melanoma differentiation-associated protein 5 (MDA5) plays a vital role in antiviral innate immune responses. In addition, the encoded protein also activates interferon regulatory factors 3 and 7 and nuclear factor-κB (NF-κB) via a mitochondrial viral signaling protein, inducing antiviral and proapoptotic responses, which is associated with various autoimmune diseases, such as type 1 diabetes (T1D), Graves′ disease (GD), multiple sclerosis (MS), psoriasis and rheumatoid arthritis (RA). Polymorphism in the gene is associated with the development of generalized vitiligo (GV).

Características e benefícios

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Ligação

The action of this antibody can be blocked using blocking peptide SBP3500356.

forma física

Supplied in PBS with 0.02% sodium azide.

Exoneração de responsabilidade

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Informações de segurança

• Código de classe de armazenamento: 10 - Combustible liquids
• Classe de risco de água (WGK): WGK 2
• Ponto de fulgor (°F): Not applicable
• Ponto de fulgor (°C): Not applicable