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S7448

Sigma-Aldrich

STF-62247

≥98% (HPLC), solid

Sinônimo(s):

N-(3-Methylphenyl)-4-(4-pyridinyl)-2-thiazolamine

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About This Item

Fórmula empírica (Notação de Hill):
C15H13N3S
Número CAS:
315702-99-9
Peso molecular:
267.35
Número MDL:
MFCD01121974
Código UNSPSC:
12352200
ID de substância PubChem:
329824583
NACRES:
NA.77

Nível de qualidade

100

Ensaio

≥98% (HPLC)

forma

solid

solubilidade

DMSO: soluble 26 mg/mL
H2O: insoluble

temperatura de armazenamento

room temp

cadeia de caracteres SMILES

Cc1cccc(Nc2nc(cs2)-c3ccncc3)c1

InChI

1S/C15H13N3S/c1-11-3-2-4-13(9-11)17-15-18-14(10-19-15)12-5-7-16-8-6-12/h2-10H,1H3,(H,17,18)

chave InChI

KATNUHQNJGNLPW-UHFFFAOYSA-N

Aplicação

STF-62247 may be used as positive control in autophagy inducing cell signaling studies.

Ações bioquímicas/fisiológicas

STF-62247 induces the formation of large vacuoles in the von Hippel-Lindau deficient renal carcinoma cells, a characteristic of autophagy.1
STF-62247 is a selective inducer of autophagy in VHL-deficient renal cell carcinoma cells.

Frases de perigo

H413

Declarações de precaução

P273 - P501

Classificações de perigo

Aquatic Chronic 4

Código de classe de armazenamento

11 - Combustible Solids

Classe de risco de água (WGK)

WGK 2

Equipamento de proteção individual

dust mask type N95 (US), Eyeshields, Gloves, type P2 (EN 143) respirator cartridges

Certificados de análise (COA)

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Sandra Turcotte et al.
Autophagy, 4(7), 944-946 (2008-09-05)
Radiation and conventional cytotoxic chemotherapies are ineffective in treating renal cancer. Approximately 75 percent of renal cell carcinoma (RCC) is associated with an inactivation of the tumor suppressor gene von Hippel-Lindau (VHL). We exploited the possibility of targeting VHL-deficient RCC
Tomohiro Kozako et al.
BMC cancer, 18(1), 791-791 (2018-08-08)
Sirtuin 2 (SIRT2) is a member of the sirtuin family, nicotinamide adenine dinucleotide+-dependent deacylases, which participates in modulation of cell cycle control, neurodegeneration, and tumorigenesis. SIRT2 expression increases in acute myeloid leukemia blasts. Downregulation of SIRT2 using siRNA causes apoptosis
Kanchan Phadwal et al.
Autophagy, 8(4), 677-689 (2012-02-04)
Autophagy is a conserved constitutive cellular process, responsible for the degradation of dysfunctional proteins and organelles. Autophagy plays a role in many diseases such as neurodegeneration and cancer; however, to date, conventional autophagy detection techniques are not suitable for clinical
Maximilian N Kinzler et al.
Scientific reports, 10(1), 687-687 (2020-01-22)
Induction of autophagy can have beneficial effects in several human diseases, e.g. cancer and neurodegenerative diseases (ND). Here, we therefore evaluated the potential of two novel autophagy-inducing compounds, i.e. STF-62247 and pimozide, to stimulate autophagy as well as autophagic cell
Nadia Bouhamdani et al.
American journal of physiology. Cell physiology, 316(5), C605-C620 (2019-02-14)
Autophagy is a highly conserved, homeostatic process by which cytosolic components reach lysosomes for degradation. The roles played by different autophagic processes in cancer are complex and remain cancer type and stage dependent. Renal cell carcinoma (RCC) is the most
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