RAB0441
Phospho-Stat1 (pSer727) and pan-Stat1 ELISA Kit
for detection of phospho-stat1 (pSer727) and pan-stat1 in human or mouse cell and tissue lysates
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About This Item
Código UNSPSC:
41116158
NACRES:
NA.32
Produtos recomendados
reatividade de espécies
mouse, human
técnica(s)
ELISA: suitable
capture ELISA: suitable
Condições de expedição
wet ice
temperatura de armazenamento
−20°C
Informações sobre genes
human ... STAT1(6772)
mouse ... STAT1(20846)
Descrição geral
The Phospho-Stat1 (pSer727) ELISA (Enzyme-Linked Immunosorbent Assay) kit is a very rapid, convenient and sensitive assay kit that can monitor the activation or function of important biological pathways in cell lysates.
Imunogênio
Stat1 (pTyr727) synthetic phosphopeptide, Recombinant Human STAT1
Aplicação
For research use only. Not for use in diagnostic procedures.
Please refer to the attached General ELISA KIT Procedure (sandwich, competitive & Indirect ELISA)
Please refer to the attached General ELISA KIT Procedure (sandwich, competitive & Indirect ELISA)
Ações bioquímicas/fisiológicas
Signal transducer and activator of transcription 1 (STAT1) undergoes phosphorylation on serine-727. This Phospho-Stat1 regulates pro- and anti-apoptotic genes following several stress-induced responses. STAT-1 interacts with p53 and promotes p53-mediated transcriptional gene activity and apoptosis. STAT-1 is an essential factor of stress-induced and DNA damage-induced checkpoint pathways and thus, acts as a tumour suppressor. STAT-1 functions as a pro-apoptotic factor in cardiac myocytes, brain or liver exposed to ischaemia–reperfusion injury. Thus, inhibition of STAT-1-activated pathway by epigallocatechin-3-gallate (EGCG), can be considered as a potential therapeutic method against ischaemic tissue injury. Repression of STAT-1 expression by human papillomavirus (HPV) oncoproteins E6 and E7 at transcription level is essential for genome amplification and maintenance of episomes, which is suggested to have a crucial role in viral pathogenesis.
Palavra indicadora
Warning
Frases de perigo
Classificações de perigo
Met. Corr. 1 - STOT SE 3
Órgãos-alvo
Respiratory system
Código de classe de armazenamento
8A - Combustible corrosive hazardous materials
Certificados de análise (COA)
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Epigallocatechin-3-gallate inhibits STAT-1 activation and protects cardiac myocytes from ischemia/reperfusion-induced apoptosis.
Townsend PA
Faseb Journal, 18(13), 1621-1623 (2004)
Suppression of STAT-1 expression by human papillomaviruses is necessary for differentiation-dependent genome amplification and plasmid maintenance.
Hong S
Journal of Virology, 85(18), 9486-9494 (2011)
STAT-1: a novel regulator of apoptosis.
Stephanou A and Latchman DS
International Journal of Experimental Pathology, 84(6), 239-244 (2003)
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