RAB0166
Phospho-EGFR (pTyr1068) and pan-EGFR ELISA Kit
for detection of human phospho-egfr (pTyr1068) and pan-egfr in cell and tissue lysates
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About This Item
Produtos recomendados
reatividade de espécies
human
embalagem
kit of 96 wells (12 strips x 8 wells)
técnica(s)
ELISA: suitable
capture ELISA: suitable
entrada
sample type: human cell lysate
sample type: human tissue lysate
método de detecção
colorimetric
Condições de expedição
wet ice
temperatura de armazenamento
−20°C
Informações sobre genes
human ... EGFR(1965)
Descrição geral
The Phospho-EGFR (pTyr1068) ELISA (Enzyme-Linked Immunosorbent Assay) kit is a very rapid, convenient and sensitive assay kit that can monitor the activation or function of important biological pathways in cell lysates.
Imunogênio
EGFR (pTyr1068) synthetic phosphopeptide, Recombinant Human EGFR
Aplicação
For research use only. Not for use in diagnostic procedures.
Please refer to the attached General ELISA KIT Procedure (sandwich, competitive & Indirect ELISA)
Please refer to the attached General ELISA KIT Procedure (sandwich, competitive & Indirect ELISA)
Ações bioquímicas/fisiológicas
EGFR (epidermal growth factor receptor) functions as a receptor for EGF-family of proteins, which are peptide growth factors. This receptor-ligand system is also involved in the pathogenesis and progression of various types of carcinomas. In cancer, EGFR pathways promotes cellular proliferation, angiogenesis, metastasis and apoptosis. The microRNA miR-218-5p interacts with and controls EGFR, and in non-small cell lung cancer (NSCLC), the levels of EGFR are inversely related to miR-218-5p. miR-218-5p inhibits proliferation and migration of lung cancer cells by binding with EGFR, and thus, has potential in future NSCLC therapies. Phospho-EGFR activates phospho-Akt pathway in invasive bladder cancer (BC) and it can be considered as a promising therapeutic target for cancer.
Outras notas
Phosphorylated and pan protien can both be measured , in one experimnet.
Palavra indicadora
Warning
Frases de perigo
Declarações de precaução
Classificações de perigo
Met. Corr. 1
Código de classe de armazenamento
8B - Non-combustible corrosive hazardous materials
Classe de risco de água (WGK)
WGK 3
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Encontre a documentação dos produtos que você adquiriu recentemente na biblioteca de documentos.
Phospho-Akt pathway activation and inhibition depends on N-cadherin or phospho-EGFR expression in invasive human bladder cancer cell lines.
Urologic Oncology, 28(2), 180-188 (2010)
A novel approach in the treatment of cancer: targeting the epidermal growth factor receptor.
Clinical Cancer Research, 7(10), 2958-2970 (2001)
Tumor-suppressive miR-218-5p inhibits cancer cell proliferation and migration via EGFR in non-small cell lung cancer.
Oncotarget, 7(19), 28075-28085 (2016)
Epidermal growth factor receptor (EGFR) signaling in cancer.
Gene, 366(1), 2-16 (2006)
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