R8154

Monoclonal Anti-RAP1 antibody produced in mouse

~2 mg/mL, clone 4C8/1, purified immunoglobulin, buffered aqueous solution

• Sinônimo(s): Anti-TERF2-Interacting Protein, Anti-TERF2IP
• Número MDL: MFCD08705598
• Código UNSPSC: 12352203
• NACRES: NA.41

Propriedades

• fonte biológica: mouse
• Nível de qualidade: 200
• conjugado: unconjugated
• forma do anticorpo: purified immunoglobulin
• tipo de produto de anticorpo: primary antibodies
• clone: 4C8/1, monoclonal
• forma: buffered aqueous solution
• peso molecular: antigen ~47 kDa
• reatividade de espécies: human
• concentração: ~2 mg/mL
• técnica(s): indirect ELISA: suitable; microarray: suitable; western blot: 0.1-0.2 μg/mL using HeLa total cell extract.
• Isotipo: IgG2b
• nº de adesão UniProt: Q9NYB0
• Condições de expedição: dry ice
• temperatura de armazenamento: −20°C
• modificação pós-traducional do alvo: unmodified
• Informações sobre genes: human ... TERF2IP(54386)

Descrição

Descrição geral

Monoclonal Anti-RAP1 (mouse IgG2b isotype) is derived from the hybridoma 4C8/1 produced by the fusion of mouse myeloma cells (Sp2/0 Ag.14 cells) and splenocytes from BALB/c mice immunized with human RAP1. Ras-related protein 1 (RAP1) protein contains 399 amino acids with an acidic C-terminus featuring a 33 amino acid coiled-coil region and a bipartite nuclear localization signal. It is expressed ubiquitously, is located at telomeres and affects telomer length.

Rap1 (repressor/activator protein) is a constituent of shelterin. It consists of an N-terminal BRCT motif, a C-terminal protein interaction domain, and one or two central Myb domains. It is also known as Terf2ip (TERF2 interacting protein). It is located on chromosome 16q23.1.

Imunogênio

human RAP1.

Aplicação

Monoclonal Anti-RAP1 antibody produced in mouse may be used in enzyme linked immunosorbent assay (ELISA) and immunoblotting.

Ações bioquímicas/fisiológicas

Rap1 (repressor/activator protein) helps to guard telomeres, assemble telomerase, and controls telomere length. At telomeres, Rap1 also participates in the suppression of non-homologous end joining (NHEJ). It involves in genomewide transcriptional modulation. Knockdown of Rap1 induces apoptosis in hepatocellular carcinoma cell line HepG2.

forma física

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.

Exoneração de responsabilidade

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Informações de segurança

• Código de classe de armazenamento: 10 - Combustible liquids
• Classe de risco de água (WGK): WGK 3
• Ponto de fulgor (°F): Not applicable
• Ponto de fulgor (°C): Not applicable
• Equipamento de proteção individual: Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)