PZ0159

MCOPPB trihydrochloride hydrate

>98% (HPLC)

• Sinônimo(s): 1-[1-(1-Methylcyclooctyl)-4-piperidinyl]-2-[(3R)-3-piperidinyl]-1H-benzimidazole trihydrochloride hydrate
• Fórmula empírica (Notação de Hill): C₂₆H₄₀N₄ · 3 HCl · xH₂O
• Número CAS: 1028969-49-4
• Peso molecular: 518.01 (anhydrous basis)
• Código UNSPSC: 51111800
• ID de substância PubChem: 329823741
• NACRES: NA.77

Propriedades

• Nível de qualidade: 100
• Ensaio: >98% (HPLC)
• forma: powder
• condição de armazenamento: desiccated
• cor: white to tan
• solubilidade: H₂O: ≥13 mg/mL
• temperatura de armazenamento: room temp
• cadeia de caracteres SMILES: O.Cl.Cl.Cl.CC1(CCCCCCC1)N2CCC(CC2)n3c(nc4ccccc34)[C@@H]5CCCNC5
• InChI: 1S/C26H40N4.3ClH.H2O/c1-26(15-7-3-2-4-8-16-26)29-18-13-22(14-19-29)30-24-12-6-5-11-23(24)28-25(30)21-10-9-17-27-20-21;;;;/h5-6,11-12,21-22,27H,2-4,7-10,13-20H2,1H3;3*1H;1H2
• chave InChI: UQBVSGBDJOJHIP-UHFFFAOYSA-N

Descrição

Ações bioquímicas/fisiológicas

MCOPPB trihydrochloride is a potent non-peptide nociceptin/orphanin FQ peptide (NOP)-receptor full agonist [or opioid-receptor-like-1 (ORL1) receptor agonist]. MCOPPB is the most potent novel non-peptide NOP full agonist in vitro and an orally potent anxiolytic in the mice. It inhibited signaling through the NOP receptor in the mouse brain, suggesting that it penetrated into the brain after it was orally administered. It did not affect locomotor activity or memory, nor did it contribute to ethanol-induced hypnosis.

Características e benefícios

This compound is featured on the Opioid Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Informações de segurança

• Código de classe de armazenamento: 11 - Combustible Solids
• Classe de risco de água (WGK): WGK 3
• Ponto de fulgor (°F): Not applicable
• Ponto de fulgor (°C): Not applicable