PLA0072

Rabbit anti-p53 Antibody, Affinity Purified

• Sinônimo(s): BCC7, LFS1, Li-Fraumeni syndrome, TRP53, Tumor suppressor p53, antigen NY-CO-13, mutant tumor protein 53, p53, p53 tumor suppressor, phosphoprotein p53, transformation-related protein 53, tumor protein 53, tumor supressor p53
• Código UNSPSC: 12352203
• NACRES: NA.41

Propriedades

• fonte biológica: rabbit
• Nível de qualidade: 100
• forma do anticorpo: affinity purified immunoglobulin
• tipo de produto de anticorpo: primary antibodies
• reatividade de espécies: human
• técnica(s): ChIP: 4-30 μg; flow cytometry: 1.5 μg; immunohistochemistry: 1:1,000- 1:5,000; immunoprecipitation (IP): 2-5 μg/mg; western blot: 1:2,000-1:10,000
• nº de adesão: P04637
• Condições de expedição: wet ice
• temperatura de armazenamento: 2-8°C
• modificação pós-traducional do alvo: unmodified
• Informações sobre genes: rabbit ... p53(7157)

Descrição

Descrição geral

p53, also known as transformation related protein 53 (TRP53), is encoded by the gene mapped to human chromosome 17p13.1. p53 is a tumor suppressor gene expressed in a wide variety of tissues. The gene codes for a tetrameric nuclear DNA-binding phosphoprotein.

Imunogênio

The epitope recognized by PLA0072 maps to a region between residues 50 and 100 of human tumor protein p53 using the numbering given in SwissProt entry P04637 (GeneID 7157).

Ações bioquímicas/fisiológicas

Tumor suppressor p53 has an ability to induce cell cycle arrest. It also plays a key role in DNA repair, senescence and apoptosis. It binds to simian vacuolating virus 40 (SV40) T-antigen and human papilloma virus E6 protein. Mutation in the p53 gene is associated with the development of various types of cancers, such as breast, ovarian, bladder, colon and lung cancer.

forma física

Tris-citrate/phosphate buffer, pH 7 to 8 containing 0.09% sodium azide

Outras notas

p53 is a tumor suppressor protein that is mutated or inactivated in over 50% of human cancers. Loss of function defects in p53 are the cause of the autosomal dominant familial cancer syndrome, Li-Fraumeni syndrome (LFS) that is characterized by the development of a diverse set of malignancies at very early ages. At the cellular level p53 is involved in the negative regulation of cell the cycle via its transactivational control of genes required for cell cycle progression. Depending on the physiological circumstance, p53 can promote growth arrest or apoptosis.

Exoneração de responsabilidade

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Informações de segurança

• Código de classe de armazenamento: 12 - Non Combustible Liquids
• Classe de risco de água (WGK): nwg
• Ponto de fulgor (°F): Not applicable
• Ponto de fulgor (°C): Not applicable