Pular para o conteúdo
Merck
Todas as fotos(4)

Key Documents

View All Documentation

P8399

Sigma-Aldrich

Psoralen

≥99% (HPLC)

Sinônimo(s):

6,7-Furanocoumarin, 7H-Furo[3,2-g]benzopyran-7-one, Ficusin, Furo[3,2-g]coumarin

Faça loginpara ver os preços organizacionais e de contrato
Todas as fotos(4)

About This Item

Fórmula empírica (Notação de Hill):
C11H6O3
Número CAS:
66-97-7
Peso molecular:
186.16
Beilstein:
152784
Número CE:
200-639-7
Número MDL:
MFCD00010520
Código UNSPSC:
12352200
ID de substância PubChem:
24898918
NACRES:
NA.77

Nível de qualidade

200

Ensaio

≥99% (HPLC)

forma

powder

fluorescência

λex 335 nm; λem 460 nm (pH 7.0)

temperatura de armazenamento

2-8°C

cadeia de caracteres SMILES

O=C1Oc2cc3occc3cc2C=C1

InChI

1S/C11H6O3/c12-11-2-1-7-5-8-3-4-13-9(8)6-10(7)14-11/h1-6H

chave InChI

ZCCUUQDIBDJBTK-UHFFFAOYSA-N

Procurando produtos similares? Visita Guia de comparação de produtos

Aplicação

Psoralen has been used:
  • as a crosslinker for dsRNA for in- situ hybridization studies
  • in testing melanin dispersal effects in fish scale melanophores
  • to test its stimulatory effects in osteoblast a cell proliferation assay
  • as a reference standard in high-performance liquid chromatography (HPLC)

Photochemical reagent for the investigation of nucleic acid structure and function.

Ações bioquímicas/fisiológicas

Psoralen belongs to the linear type furanocoumarins. It intercalates and induces interstrand cross-links in DNA. On UV exposure psoralen is excited leading to irreversible intercalation with DNA by covalent bond formation. This property of psoralen ultraviolet A light (PUVA) is exploited in treating skin diseases and cutaneous T-cell lymphoma. However, usage psoralen also leads to hepatotoxicity and cytotoxicity by the generation of psoralen photoproducts (POPs). It may be useful in treating osteoporosis

Características e benefícios

This compound is a featured product for Apoptosis research. Click here to discover more featured Apoptosis products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

Pictogramas

Exclamation mark
GHS07

Palavra indicadora

Warning

Frases de perigo

H302,H317

Classificações de perigo

Acute Tox. 4 Oral - Skin Sens. 1

Código de classe de armazenamento

11 - Combustible Solids

Classe de risco de água (WGK)

WGK 3

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable

Equipamento de proteção individual

dust mask type N95 (US), Eyeshields, Gloves

Certificados de análise (COA)

Busque Certificados de análise (COA) digitando o Número do Lote do produto. Os números de lote e remessa podem ser encontrados no rótulo de um produto após a palavra “Lot” ou “Batch”.

Já possui este produto?

Encontre a documentação dos produtos que você adquiriu recentemente na biblioteca de documentos.

Visite a Biblioteca de Documentos

Os clientes também visualizaram

Slide 1 of 3

1 of 3

Psoralidin ≥98% (HPLC)

Sigma-Aldrich

SML0932

Psoralidin

Bakuchicin phyproof® Reference Substance

PHL89578

Bakuchicin

Bergamottin analytical standard

Supelco

01338

Bergamottin

The mitochondrial effects of novel apoptogenic molecules generated by psoralen photolysis as a crucial mechanism in PUVA therapy
Caffieri S, et al.
Blood, 109(11), 4988-4994 (2007)
In vitro responses of fish melanophores to lyophilized extracts of Psoralea corylifolia seeds and pure psoralen
Ali SA, et al.
Pharmaceutical biology, 49(4), 422-427 (2011)
Psoralen induced liver injury by attenuating liver regenerative capability
Zhou W, et al.
Frontiers in Pharmacology, 9, 1179-1179 (2018)
Psoralen and isopsoralen ameliorate sex hormone deficiency-induced osteoporosis in female and male mice
Yuan X, et al.
BioMed Research International, 2016 (2016)
A method for in situ localization of single-strand and double-strand RNA elements contained in the hepatitis C virus genome 3?-untranslated region
Rance E, et al.
advanced techniques in biology & medicine, 4, 171-183 (2016)
Exibir todos os documentos relacionados

Artigos

DNA Damage and Repair

DNA damage and repair mechanism is vital for maintaining DNA integrity. Damage to cellular DNA is involved in mutagenesis, the development of cancer among others.

Conteúdo relacionado

Discover Bioactive Small Molecules for Apoptosis

Apoptosis, or programmed cell death (PCD), is a selective process for the removal of unnecessary, infected or transformed cells in various biological systems. As it plays a role in the homeostasis of multicellular organisms, apoptosis is tightly regulated through two principal pathways by a number of regulatory and effector molecules.

Nossa equipe de cientistas tem experiência em todas as áreas de pesquisa, incluindo Life Sciences, ciência de materiais, síntese química, cromatografia, química analítica e muitas outras.

Entre em contato com a assistência técnica