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Documentos Principais

P4329

Sigma-Aldrich

1,2-Dipalmitoyl-sn-glycero-3-phosphocholine

≥99% (TLC)

Sinônimo(s):

PC, (7R)-4-Hydroxy-N,N,N-trimethyl-10-oxo-7-[(1-oxohexadecyl)oxy]- 3,5,9-trioxa-4-phosphapentacosan-1-aminium 4-oxide, inner salt, 1,2-Dihexadecanoyl-sn-glycero-3-phosphocholine, 1,2-Dihexadecanoyl-sn-glycero-3-phosphorylcholine, 1,2-Dipalmitoyl-sn-glycero-3-phosphorylcholine, 1,2-Dipalmitoyl-L-lecithin, L-α-Phosphatidylcholine, dipalmitoyl, L-β,γ-Dipalmitoyl-α-lecithin, DPPC, PC(16:0/16:0)

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About This Item

Fórmula empírica (Notação de Hill):
C40H80NO8P
Número CAS:
Peso molecular:
734.04
Número CE:
Número MDL:
Código UNSPSC:
12352211
ID de substância PubChem:
NACRES:
NA.25

fonte biológica

synthetic

Nível de qualidade

Ensaio

≥99% (TLC)

forma

powder

grupo funcional

phospholipid

tipo de lipídio

phosphoglycerides

Condições de expedição

ambient

temperatura de armazenamento

−20°C

cadeia de caracteres SMILES

[O-]P(OCC[N+](C)(C)C)(OC[C@]([H])(OC(CCCCCCCCCCCCCCC)=O)COC(CCCCCCCCCCCCCCC)=O)=O

InChI

1S/C40H80NO8P/c1-6-8-10-12-14-16-18-20-22-24-26-28-30-32-39(42)46-36-38(37-48-50(44,45)47-35-34-41(3,4)5)49-40(43)33-31-29-27-25-23-21-19-17-15-13-11-9-7-2/h38H,6-37H2,1-5H3/t38-/m1/s1

chave InChI

KILNVBDSWZSGLL-KXQOOQHDSA-N

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Aplicação


  • Effects induced by (6)-p-cymene ruthenium(II) complexes on Langmuir monolayers mimicking cancer and healthy cell membranes do not correlate with their toxicity.: This study investigates the interaction of ruthenium(II) complexes with Langmuir monolayers, including 1,2-Dipalmitoyl-sn-glycero-3-phosphocholine, highlighting differences in behavior between cancerous and healthy cell membrane models (Wrobel et al., 2024).

  • Cholesterol Changes Interfacial Water Alignment in Model Cell Membranes.: This study examines how cholesterol affects water alignment at the interface of model cell membranes that include 1,2-Dipalmitoyl-sn-glycero-3-phosphocholine, offering insights into membrane biophysics (Orlikowska-Rzeznik et al., 2024).

  • Impact of Lipid Composition on Vesicle Protein Adsorption: A BSA Case Study.: The impact of different lipid compositions, including 1,2-Dipalmitoyl-sn-glycero-3-phosphocholine, on the adsorption of bovine serum albumin to vesicles is studied to understand protein-lipid interactions (Amarandi et al., 2024).

  • Spatial Arrangement of the Drug Ibuprofen in a Model Membrane in the Presence of Lipid Rafts.: This paper investigates the arrangement of ibuprofen within model membranes containing lipid rafts and 1,2-Dipalmitoyl-sn-glycero-3-phosphocholine, shedding light on drug-membrane interactions (Kashnik et al., 2024).

Ligação

Purified by crystallization.

Código de classe de armazenamento

11 - Combustible Solids

Classe de risco de água (WGK)

WGK 3

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable


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Johannes Thoma et al.
Chemical communications (Cambridge, England), 48(70), 8811-8813 (2012-07-28)
We present a model system to demonstrate that the positioning of biomolecules (membrane proteins) in a nonnative, complex thin film environment can be regulated by the phase behavior of film components. Partial separation between an amphiphilic polymer and a lipid
Edyta Paszko et al.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 48(1-2), 202-210 (2012-11-20)
Photodynamic therapy (PDT) is based on the delivery of photocytotoxic agents to a target tissue, followed by irradiation. In order to increase the efficiency of PDT in oesophageal cancer therapy, polyethylene glycol (PEG)-grafted, transferrin (Tf)-conjugated liposome formulations of 5,10,15,20-tetra(m-hydroxyphenyl)chlorin (Foscan)
Fernando R Moya et al.
Pediatrics, 115(4), 1018-1029 (2005-04-05)
Evidence suggests that synthetic surfactants consisting solely of phospholipids can be improved through the addition of peptides, such as sinapultide, that mimic the action of human surfactant protein-B (SP-B). A synthetic surfactant containing a mimic of SP-B may also reduce
John M Franck et al.
Journal of the American Chemical Society, 135(11), 4175-4178 (2013-01-26)
The translational hydration dynamics within 0.5-1.5 nm of the surface of a DPPC liposome, a model biomacromolecular surface, is analyzed by the recently developed Overhauser dynamic nuclear polarization (ODNP) technique. We find that dramatic changes to the bulk solvent cause
Xu Hannah Zhang et al.
Journal of cell science, 120(Pt 23), 4134-4143 (2007-11-23)
The G1 phase of the cell cycle is marked by the rapid turnover of phospholipids. This turnover is regulated by CTP:phosphocholine-cytidylyltransferase (CCT) and group VIA Ca(2+)-independent-phospholipase A(2) (iPLA(2)). We previously reported that inhibition of iPLA(2) arrests cells in G1 phase

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