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P3287

Sigma-Aldrich

Protein kinase CβII isozyme human

>85% (SDS-PAGE), recombinant, expressed in baculovirus infected insect cells, buffered aqueous glycerol solution

Sinônimo(s):

Ca2+-activated phospholipid-dependent serine-threonine kinase βII isozyme human, PKC βII human

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About This Item

Número da licença da enzima:
2.7.1.37 (BRENDA, IUBMB)
Número MDL:
MFCD03458219
Código UNSPSC:
12352202
NACRES:
NA.32

recombinante

expressed in baculovirus infected insect cells

Ensaio

>85% (SDS-PAGE)

Formulário

buffered aqueous glycerol solution

atividade específica

≥500 unit/mg solid

peso molecular

80 kDa by SDS-PAGE
calculated mol wt 76.9 kDa

nº de adesão UniProt

P05771

Condições de expedição

dry ice

temperatura de armazenamento

−70°C

Informações sobre genes

human ... PRKCB(5579)

Ações bioquímicas/fisiológicas

PKCβII is involved in glucose signaling pathways.
Protein Kinase C (PKC) is a serine/threonine kinase that is activated intracellularly by signal transduction pathways that produce DAG from phosphatidylinositol diphosphate (PIP2) and phosphatidylcholine (PC) through the action of various activated phospholipases. Phorbol esters also stimulate PKC. At least 11 PKC isozymes have been identified that differ in primary structure, tissue distribution, subcellular localization, response to extracellular signals, and substrate specificity. The isozymes can be grouped into three subfamilies. Members of the first family require Ca2+ and phospholipid and include PKCα, βI, βII, and γ. Members of the second family are phospholipid-dependent but Ca2+-independent, and include PKCδ, ε, η, and θ. Members of the third family are not activated by either DAG or phorbol esters and include PKCξ, μ, and ι.
Phosphorylation appears to be an important mechanism of regulation of all PKCs. PKC plays a role in the regulation of cell transformation, growth, differentiation, ruffling, vesicle trafficking, apoptosis and gene expression.

Definição da unidade

One unit will transfer 1 nmol of phosphate to histone H3 in 1 min at pH 7.4 at 30 °C.

forma física

Solution in 20 mM HEPES, pH 7.4; 2 mM EDTA, 2 mM EGTA, 5 mM DTT, 100 mM NaCl, 0.05% Triton X-100, and 50% glycerol.

Código de classe de armazenamento

10 - Combustible liquids

Classe de risco de água (WGK)

WGK 1

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable

Equipamento de proteção individual

Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)

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Certificados de análise (COA)

Lot/Batch Number
SLBT7146
SLBV0667
076K0544
026K0609
015K2728

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Małgorzata Beręsewicz-Haller et al.
International journal of molecular sciences, 22(16) (2021-08-28)
Ischemic episodes are a leading cause of death worldwide with limited therapeutic interventions. The current study explored mitochondrial phosphate-activated glutaminase (GLS1) activity modulation by PKCβII through GC-MS untargeted metabolomics approach. Mitochondria were used to elucidate the endogenous resistance of hippocampal
Hai Huang et al.
Development (Cambridge, England), 138(12), 2477-2485 (2011-05-13)
Post-translational modification by the small ubiquitin-related modifier (SUMO) is important for a variety of cellular and developmental processes. However, the precise mechanism(s) that connects sumoylation to specific developmental signaling pathways remains relatively less clear. Here, we show that Smt3 knockdown
Sung Chul Lee et al.
Proceedings of the National Academy of Sciences of the United States of America, 104(40), 15959-15964 (2007-09-28)
Potassium (K(+)) is an essential nutrient for plant growth and development. Plants often adapt to low K(+) conditions by increasing their K(+) uptake capability. Recent studies have led to the identification of a calcium signaling pathway that enables plants to
Yong Xiang et al.
Plant physiology, 144(3), 1416-1428 (2007-05-31)
Plants respond to adverse environments by initiating a series of signaling processes that often involves diverse protein kinases, including calcineurin B-like protein-interacting protein kinases (CIPKs). In this study, putative CIPK genes (OsCIPK01-OsCIPK30) in the rice (Oryza sativa) genome were surveyed
Cecilia D'Angelo et al.
The Plant journal : for cell and molecular biology, 48(6), 857-872 (2006-11-10)
Intracellular release of calcium ions belongs to the earliest events in cellular stress perception. The molecular mechanisms integrating signals from different environmental cues and translating them into an optimized response are largely unknown. We report here the functional characterization of
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